毛细支气管炎患儿血清25-羟基维生素D水平变化  

Changes of Serum 25-hydroxyvitamin D Level in Children with Bronchiolitis

作　　者：鲍灵芝[1] 马桂香[1] 王建亮[1] 马宁[1] 王霞[1] 李艳[1] 马萱 庞芸[1] 王爱霞[1] 李娟[1] 王玲华 张艳华[1] BAO Lingzhi;MA Guixiang;WANG Jianliang;MA Ning;WANG Xia;LI Yan;MA Xuan;PANG Yun;WANG Aixia;LI Juan;WANG Linghua;ZHANG Yanhua(the Second People’Hospital of Shizuishan in Ningxia,Shizuishan 753000,China)

机构地区：[1]宁夏石嘴山市第二人民医院

出　　处：《宁夏医科大学学报》2019年第5期479-482,共4页Journal of Ningxia Medical University

基　　金：石嘴山市科技公关项目(2017-38b)

摘　　要：目的探讨补充维生素D(Vitamin D,VitD)对毛细支气管炎患儿的治疗效果,为毛细支气管炎补充维生素D治疗提供新的理论依据。方法选择毛细支气管炎伴VitD不足及缺乏患儿80例,以患儿家长签署毛细支气管炎补充VitD治疗知晓同意书为依据,分为研究组(37例)与对照组(43例),两组患儿均给予抗病毒、抗感染及对症治疗,在此治疗的基础上研究组加用VitD治疗,疗程1个月;对照组为未补充VitD治疗。采用电化学发光法检测患儿血清25羟维生素D3[25-hydroxyvitamin D3,25-(OH)D3]水平,同时观察并记录治疗期间两组患儿喘憋消失时间、肺部体征消失时间、住院天数及随访期患儿喘息复发次数。结果治疗前研究组与对照组血清25-(OH)D3水平差异无统计学意义(P>0.05);治疗后研究组血清25-(OH)D3水平高于同组治疗前和对照组(P均<0.01)。与对照组比较,研究组患儿喘憋消失天数减少,肺部体征消失天数缩短、住院天数减少和喘息复发次数减少(P均<0.05)。结论维生素D缺乏可能是毛细支气管炎的潜在病因;补充维生素D能够及时缓解毛细支气管炎患儿的临床症状,降低毛细支气管炎再发率。Objective To explore the therapeutic effect of vitamin D supplementation(Vitamin D,VitD)on children with bronchiolitis,and to provide a new theoretical basis for the treatment of bronchiolitis with vitamin D supplementation.Methods Eighty children with bronchiolitis accompanied by VitD deficiency and deficiency were selected and divided into study group(37 cases)and control group(43 cases)based on the informed consent of parents to supplement of VitD for bronchiolitis.Both groups were given antiviral,anti-infective and symptomatic treatment.On the basis of this treatment,the study group was treated with VitD for one month,while the control group was treated with VitD without supplementation.Serum 25-hydroxyvitamin D3[25-hydroxyvitamin D3,25-(OH)D3]levels were measured by electro-chemiluminescence.The disappearance time of asthma,disappearance time of pulmonary signs,hospitalization days and recurrence times of asthma were observed and recorded during treatment.Results There was no significant difference in serum 25-(OH)D3 level between the study group and the control group before treatment(P>0.05);serum 25-(OH)D3 level in the study group after treatment was higher than that before treatment and in the control group(P all<0.01).Compared with the control group,the days of wheezing disappearance,the days of pulmonary signs disappearance,the days of hospitalization and the times of wheezing recurrence in the study group decreased(P all<0.05).Conclusion Vitamin D deficiency may be a potential cause of bronchiolitis.Vitamin D supplementation therapy can alleviate the clinical symptoms of bronchiolitis in children and reduce the recurrence rate of bronchiolitis.

关 键 词：维生素D缺乏 毛细支气管炎 血清羟维生素D3 

分 类 号：R725.6[医药卫生—儿科]