鱼金注射液联合噻托溴铵对哮喘-慢阻肺重叠综合征FeNO及免疫功能的影响研究  

Effects of Yujin injection and tiotropium bromide on FeNO and immune function in asthma-COPD overlapping syndrome

作　　者：尚晓霞 SHANG Xiaoxia(Department of Respiratory Medicine, Daqing Longnan Hospital, Daqing 163000, China)

机构地区：[1]大庆龙南医院呼吸内科

出　　处：《包头医学院学报》2019年第5期26-27,共2页Journal of Baotou Medical College

摘　　要：目的:评估且分析在哮喘-慢阻肺重叠综合征患者中应用噻托溴铵与鱼金注射液联合吸入治疗的临床效果。方法:以抽签法将来源于2016年9月至2018年9月期间的70例哮喘-慢阻肺重叠综合征患者进行分组研究,每组35例,对照组行噻托溴铵吸入治疗,观察组行噻托溴铵与鱼金注射液联合吸入治疗,比较两组患者的治疗效果以及对FeNO以及免疫功能影响。结果:观察组有效救治率为94.28%,显著优于对照组的71.42%(P<0.05)。治疗前,对照组FeNO水平与观察组比较无明显差异(P>0.05);治疗后,观察组FeNO水平明显优于对照组(P<0.05)。观察组不良反应发生率为31.42%,与对照组的11.42%比较有显著差异(P<0.05)。治疗前,两组患者Th1、Th2、Th1/Th2水平无明显差异(P>0.05);治疗后,两组Th1、Th2、Th1/Th2水平差异显著(P<0.05)。结论:将噻托溴铵与鱼金注射液联合吸入治疗对哮喘-慢阻肺重叠综合征患者有良好的治疗效果,且能抑制炎性反应,增强免疫功能。Objective:To evaluate and analyze the clinical effect of inhalation of tiotropium bromide combined with Yujin injection in patients with asthma-COPD overlap syndrome.Methods: Seventy patients with asthma-COPD overlap syndrome from September 2016 to September 2018 were divided into two groups, with 35 in each group. The patients in control group were treated with tiotropium bromide inhalation, while the patients in observation group were treated with tiotropium bromide combined with Yujin injection inhalation. The therapeutic effects, the effects on FeNO and immune function between the two groups were compared.Results: The statistical value of effective treatment in the observation group was 94.28 %, which was significantly better than that in the control group (71.42 %). There was a statistical difference between the two groups ( P < 0.05). The level of FeNO in the control group was higher than that in the observation group before treatment, but there was no statistical significance between the data ( P >0.05). After treatment, the level of FeNO in the observation group was better than that in the control group ( P <0.05), and the statistical significance was shown between the data indicators. The total value of adverse reactions in the observation group was 31.42 %, compared with that in the control group (11.42 %), indicating a statistical significance ( P <0.05). Before treatment, there was no significant difference in Th1, Th2, Th1/Th2 between the two groups ( P >0.05). After treatment, there were significant differences in Th1, Th2, Th1/Th2 between the two groups ( P <0.05), indicating statistical significance.Conclusion: Inhalation of tiotropium bromide combined with Yujin injection has a good therapeutic effect on asthma-COPD overlap syndrome, and can inhibit inflammatory response and enhance immune function.

关 键 词：噻托溴铵 鱼金注射液 哮喘-慢阻肺重叠综合征 FENO 免疫功能 

分 类 号：R563.9[医药卫生—呼吸系统] R562.25[医药卫生—内科学]