NAT2基因多态性与云南汉族华法林剂量的相关性  

Correlation between NAT2 Polymorphism and Warfarin Dose for Han Population in Yunnan Province

作　　者：欧阳培刚 张桂敏[1] 刘寅强[2] OUYANG Pei-gang;ZHANG Gui-min;LIU Yin-qiang(Dept.of Cardiovascular Surgery,The 1st Affiliated Hospital of Kunming Medical Universit,Kunming Yunnan 650032,China;Dept.of Geriatric Thoracic Surgery,The 1st Affiliated Hospital of Kunming Medical Universit,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院心脏大血管外科,云南昆明650032 [2]昆明医科大学第一附属医院老年胸外科,云南昆明650032

出　　处：《昆明医科大学学报》2019年第7期25-29,共5页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467(-142)];云南省卫生科技计划项目(2017NS020);云南省卫生和计划生育委员会医学后备人才培养计划(H-2017013);2018年CSCO基金资助项目(Y-Q201802-011)

摘　　要：目的探讨NAT2基因型在云南汉族人群中的分布并研究其基因多态性对瓣膜置换术后华法林稳定剂量的影响。方法检测研究对象基因型在各位点情况,研究其等位基因频率及基因型表现;研究基因多态性和华法林稳定剂量的关系。结果各位点基因型及等位基因频率分布符合Hardy-winberg遗传平衡(P>0.05);NAT2(rs1801280)、NAT2(rs1799929)、NAT2(rs1208)经统计学分析,上述基因位点多态性与华法林稳定剂量差异没有相关性(P>0.05)。结论云南汉族NAT2(rs1801280)、NAT2(rs1799929)、NAT2(rs1208)基因多态性可能不是瓣膜置换术后华法林个体剂量差异的影响因素。Objective To investigate the genotype distribution for Chinese Han population in Yunnan province and the correlation in NAT2 polymorphism and the warfarin stable dose in the patient after valve replacement.Methods The genotypes of cases were detected in order to explore the genotype and allele frequencies.The cases after valve replacement were investigated the correlation between gene polymorphism and the stable dose of warfarin.Results All genotypes and allele frequencies met with Hardy-winberg genetic balance(P > 0.05).There were no statistical difference between warfarin stable dose and different genotypes in NAT2 (P < 0.05).Conclusion Gene polymorphism of these gene sites for Yunnan Han population were not important factors which affected warfarin stable dose in the patients after the operation.

关 键 词：基因多态性 华法林 瓣膜置换术 NAT2 

分 类 号：R654.2[医药卫生—外科学]