麝香通心滴丸药物作用机制和药物靶点的研究进展  

Advances in Research on Mechanisms and Targets of Thyme Heart-Dredging Dropping Pills

作　　者：陈照云 黄兴[2] 周立华[2] 刘庆乐[2] 张翠萍[1] 李娇 李雪倩 CHEN Zhao-yun;HUANG Xing;ZHOU Li-hua;LIU Qing-le;ZHANG Cui-ping;LI jiao;LI Xue-qian(Henan University of CM,Zhengzhou,Henan,China,450046;The Third Affiliated Hospital of HenanUniversity of CM ,Zhengzhou,Henan,China ,450003)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第三附属医院,河南郑州450003

出　　处：《河南中医》2019年第7期1117-1121,共5页Henan Traditional Chinese Medicine

基　　金：河南中医药大学博士基金项目(00104354-2018-23)

摘　　要：麝香通心滴丸的药物作用机制主要是降低炎性因子、改善内皮功能、抗凋亡、抑制RAAS系统、稳定斑块、改善心肌纤维化,其药物作用靶点主要是e NOS、MicroRNAs、P13K/Akt、Lp-PLA2。中医药作为冠状动脉粥样硬化性心脏病(简称冠心病)的特色治疗方式,对冠心病的防治有独特的优势。目前,对麝香通心滴丸防治冠心病的机制和药物作用靶点研究不断增加,但因中医药研究技术有限,缺乏系统化和标准化的研究方法,导致其机制和药物靶点的精准研究受到较大限制。另一方面,麝香通心滴丸的药物作用机制和药物靶点进一步研究是建立在冠心病机制研究进展的基础上,伴随着冠心病机制和相关药物靶点进一步研究,麝香通心滴丸的研究将更加深入、全面。The pharmacological mechanism of Thyme Heart-Dredging Dropping Pills is mainly to reduce inflammatory factors,improve endothelial function,resist apoptosis,inhibit RAAS system,stabilize plaque and improve myocardial fibrosis. Its main targets are eN OS,microRNAs,P13 K/Akt and Lp-PLA2. As a characteristic treatment of coronary heart disease,TCM has unique advantages in the prevention and treatment of coronary heart disease. At present,the research on the mechanism and drug targets of Thyme Heart-Dredging Dropping Pills in the prevention and treatment of coronary heart disease is increasing. However,due to the limited research technology of TCM and lack of systematic and standardized research methods,the precise study of its mechanism and drug targets is greatly limited. On the other hand,the further study on the mechanism and target of Thyme Heart-Dredging Dropping Pills is based on the research progress of the mechanism of coronary heart disease. With the further study on the mechanism of coronary heart disease and related drug targets,the study of Thyme Heart-Dredging will be deeper and comprehensive.

关 键 词：麝香通心滴丸 冠状动脉粥样硬化性心脏病 机制 药物靶点 

分 类 号：R285[医药卫生—中药学]