基于事件相关电位P300探讨通督益阳灸法改善脑梗死后认知功能障碍  

Exploration of Tongdu Yiyang Moxibustion on Improving Cognitive Dysfunction After Cerebral Infarction Based on Event-related Electric Potential P300

作　　者：郑美 江一静 陈雨 邹愉龙 黄赛娥 ZHENG Mei;JIANG Yijing;CHEN Yu;ZOU Yulong;HUANG Saie(Rehabilitation Hospital Affiliated to Fujian University of Chinese Medicine,Fuzhou Fujian China 350003;Fujian Rehabilitation Industry Research Institute,Fuzhou Fujian China 350003)

机构地区：[1]福建中医药大学附属康复医院,福建福州350003 [2]福建省康复产业研究院,福建福州350003

出　　处：《中医学报》2019年第7期1546-1550,共5页Acta Chinese Medicine

基　　金：福建省科技厅科技平台项目(2015Y20001)

摘　　要：目的:观察通督益阳灸法对脑梗死后认知障碍患者认知功能的影响。方法:将57例脑梗死患者随机分为治疗组29例和对照组28例。治疗组采用通督益阳灸配合认知功能训练治疗,对照组仅采用认知功能训练治疗。比较两组治疗前后Barthel指数(modified barthel index,MBI)评分、蒙特利尔认知评价量表(montreal cognitive assessment,MoCA)评分及事件相关电位P300情况。结果:两组治疗后MoCA量表各项评分与同组治疗前比较均有所提高,差异具有统计学意义(P <0. 05)。治疗组治疗后MoCA量表各项评分与对照组比较均有所提高,差异具有统计学意义(P <0. 05)。两组患者治疗后MBI评分与治疗前比较,差异具有统计学意义(P <0. 01);治疗组治疗后MBI评分与对照组比较,差异具有统计学意义(P <0. 05)。两组治疗后P300波幅、潜伏期与同组治疗前比较,差异均具有统计学意义(P <0. 01)。治疗组治疗后P300波幅、潜伏期与对照组比较,波幅升高,潜伏期缩短,差异具有统计学意义(P <0. 05)。P300波幅与MoCA评分呈正相关性,P300潜伏期与MoCA评分呈负相关性。结论:通督益阳灸可改善脑梗死后认知障碍患者的认知功能。Objective: To observe the effect of Tongdu Yiyang moxibustion on cognitive function of patients with cognitive dysfunction after cerebral infarction. Methods :7 patients with cerebral infarction were randomly divided into treatment group (29 cases) and control group ( 28 cases). The treatment group was treated with Tongdu Yiyang moxibustion combined with cognitive function training, while the control group was treated with cognitive function training only. The modified barthel index ( MBI) score,montre? al cognitive assessment ( MoCA) score and event-related electric potential P300 were compared before and after treatment. Results :After treatment, the scores of MoCA scale in both groups were improved compared with those before treatment, and the difference was statistically significant (P < 0. 05). After treatment, the scores of MoCA scale in the treatment group were improved compared with those in the control group, and the difference was statistically significant ( P < 0. 05 ). There was significant difference in MBI scores between the two groups before and after treatment (P <0. 01 ). After treatment,the MBI scores of the treatment group were significantly different from that of the control group(P <0. 05). There were significant differences in the amplitude and latency of P300 between the two groups before and after treatment (P <0. 01 ). After treatment,the amplitude and latency of P300 in the treatment group were higher and shorter than those in the control group (P < 0. 05 ). The amplitude of P300 was positively correlated with MoCA score, while the latency of P300 was negatively correlated with MoCA score. Conclusion: Tongdu Yiyang Moxibustion can improve cognitive function of patients with cognitive dysfunction after cerebral infarction.

关 键 词：脑梗死 认知功能障碍 通督益阳灸法 麦粒灸 事件相关电位P300 针灸疗法 

分 类 号：R255.2[医药卫生—中医内科学]