异甘草素抗肿瘤药理作用机制的研究  

The Mechanism of Antitumor Pharmacological Effects of Isoliquiritigenin

作　　者：薛慧 王加茹 徐宛婷 张翼[1] 罗英花[2] 金成浩[1] XUE Hui;WANG Jiaru;XU Wanting;ZHANG Yi;LUO Yinghua;JIN Chenghao(College of Life Science&Technology,Heilongjiang Bayi Agricultural University,Daqing,Heilongjiang 163319,China;College of Animal Science&Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing,Heilongjiang 163319,China)

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163319 [2]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319

出　　处：《农产品加工》2019年第14期69-70,共2页Farm Products Processing

基　　金：黑龙江省科学基金项目(LC2015036);黑龙江省博士后科研启动资助项目(LBH-Q13132)

摘　　要：异甘草素是从甘草干燥根茎中提取的一种黄酮类化合物,具有抗炎、抗肿瘤、抗氧化、抗自由基等多种药理作用。研究发现,异甘草素可以通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡及抗新血管生成等途径发挥抗肿瘤作用。对近年来异甘草素的抗肿瘤活性和作用机制进行综述。Isoliquiritigenin is a kind of flavonoid compound extracted from the dried root of licorice,which has many pharmacological effects such as anti-inflammatory,anti-tumor,anti-oxidation and anti-free radical. It was found that isoliquiritigenin could play an anti-tumor role by inducing tumor cell apoptosis and inhibiting tumor cell proliferation,anti-angiogenesis. In this article,the anti-tumor effects and mechanism of isoliquiritigenin in recent years were reviewed.

关 键 词：异甘草素 抗肿瘤作用 细胞增殖 细胞凋亡 

分 类 号：R285[医药卫生—中药学]