米拉贝隆治疗膀胱过度活动症疗效的荟萃分析  

Efficacy of Mirabegron in treatment of overactive bladder: a meta analysis

作　　者：刘晓彤[1] 傅崇德[1] 李涛[1] 陈广瑜[1] 晋武玲 张茜 魏乔红[1] 焦林[1] 高辉[1] 谢圣陶 Liu Xiaotong;Fu Chongde;Li Tao;Chen Guangyu;Jin Wuling;Zhang Qian;Wei Qiaohong;Jiao Lin;Gao Hui;Xie Shengtao(Department of Urology,Xi′an Aerospace General Hospital,Shanxi 710100,China)

机构地区：[1]陕西西安航天总医院泌尿外科

出　　处：《中国药物与临床》2019年第14期2340-2343,共4页Chinese Remedies & Clinics

基　　金：西安航天总医院科研项目(2018KY005)

摘　　要：目的系统评价米拉贝隆治疗膀胱过度活动症(OAB)的临床效果和安全性。方法计算机检索 Pubmed、Cochrane library、 Sciverce、中国知网、维普及万方数据库,检索时间截止2018年4月,收集文献并分析。结果共纳入11篇RCTs。Meta分析结果显示:与索利那新5 mg比较,米拉贝隆50 mg能够改善排尿次数(P=0.03)和急迫性尿失禁(P=0.02)发生率,并且具有较低的药物相关不良反应(P=0.0003)。与托特罗定4 mg比较,米拉贝隆50 mg在改善排尿次数(P=0.67)、尿失禁(P=0.18)、急迫性尿失禁(P=0.36)方面无优势,然而其药物相关不良反应(P<0.00001)发生率较低。与索利那新单药比较,米拉贝隆与索利那新联合能够有效缓解尿失禁和夜尿次数(P均<0.05)。结论治疗OAB时米拉贝隆能够取得与索利那新、托特罗定相当的疗效,并且不增加药物相关不良反应,可作为临床治疗OAB的一种选择。Objective To systematically review the clinical efficacy and safety of Mirabegron in the treatment of overactive bladder (OAB).Methods Internet search in databases including Pubmed,Cochrane library,Sciverce,CNKI,VIP and Wanfang was performed to collect and analyze studies published up to April 2018.Results A total of 11 randomized clinical trials (RCTs) were included.Meta-analysis: Compared with 5 mg Solifenacin,50 mg Mirabegronimproved the micturition frequency (P=0.03) and incidence of urgency urinary incontinence (P=0.02) with lower incidence of drug-related side effects (P=0.0003).Compared with 4 mg Tolterodine,50 mg Mirabegron showed no advantages in improving micturition frequency (P=0.67) and incidences of urinary incontinence (P=0.18) and urgency urinary incontinence (P=0.02),however,its incidence of drug-related side effects was low (P<0.00001).Compared with Solifenacin therapy alone,the combination of Mirabegron and Solifenacin effectively relieved urinary incontinence and nocturia (both P<0.05).Conclusion Mirabegron achieves comparable efficacy with Solifenacin or Tolterodine in the treatment of OAB,without increasing drug-related side effects.It may be used as an option for clinical treatment of OAB.

关 键 词：尿失禁 米拉贝隆 META分析 

分 类 号：R694[医药卫生—泌尿科学]