多囊卵巢综合征患者临床代谢指标对子宫内膜病变的影响  

Effects of clinical metabolic indexes on endometrial lesions in patients with polycystic ovarian syndrome

作　　者：张勇[1] 张红霞[1] 任春娥[1] 王桂丽[1] ZHANG Yong;ZHANG Hongxia;REN Chune;WANG Guili(Department of Obstetrics and Gynecology,Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院妇产科学教研室

出　　处：《潍坊医学院学报》2019年第3期228-231,共4页Acta Academiae Medicinae Weifang

摘　　要：目的分析多囊卵巢综合征(PCOS)患者常见临床指标对子宫内膜病变的影响。方法选取2017年6月~2018年6月于潍坊医学院生殖医院行辅助生殖技术(ART)的200例不孕患者,100例PCOS患者为实验组(PCOS组),并以月经规律、因输卵管因素或男性因素导致不孕者100例作为对照组,收集其基础内分泌、代谢指标、血常规及宫腔镜等结果,进行对比分析。并根据PCOS患者的宫腔镜检查结果,将其分为两组,A组(子宫内膜息肉和/或息肉样增生),B组(大致正常宫腔),将两组进行上述指标的分析。结果 PCOS组体重指数(BMI)、黄体生成素(LH)、睾酮(T)、总胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、白细胞(WBC)等均高于对照组,差异均具有统计学意义(P<0.05);PCOS组宫腔异常率41例(41%)高于对照组14例(14%),差异具有统计学意义(P<0.05);A组(子宫内膜息肉和/或息肉样增生)LH、T值低于B组(大致正常宫腔),差异具有统计学意义(P<0.05)。结论 PCOS患者更容易出现子宫内膜的异常改变。子宫内膜息肉和/或息肉样增生的发生可能与LH、T有关。PCOS患者临床实验室指标表现为慢性炎症、内分泌及脂代谢异常。Objective To discuss how the clinical metabolic indexes of patients with polycystic ovarian syndrome(PCOS) affect on endometrial lesions.Methods Two hundred infertile patients who received assisted reproductive technology(ART) from June 2017 to June 2018 in Reproductive Hospital of Weifang Medical University were selected,100 patients with PCOS were selected as experimental group(PCOS group),100 patients with infertility due to tubal factors or male factors were chosen as control group,and their basic endocrine,metabolic indicators,blood routine test and the results of hysteroscopy were collected for comparative analysis.According to the results of hysteroscopy in patients with PCOS,they were divided into two groups:group A(endometrial polyp and/or polypoid hyperplasia),group B(approximately normal uterine cavity) and the above indicators were analysed.Results Body mass index,luteinizing hormone,testosterone,total cholesterol,triglyceride,low density lipoprotein cholesterol and white blood cell in PCOS group were significant higher than those in control group(P<0.05).The abnormal rate of uterine cavity in PCOS group(41%) was significantly higher than that in control group(14%)(P<0.05).The LH,T of group A(endometrial polyps and/or polypoid hyperplasia) was lower than that of group B(normal uterine cavity),and the difference was statistically significant(P<0.05).Conclusion Abnormal changes of endometrium are more likely in PCOS patients.The occurrence of endometrial polyps and/or polypoid hyperplasia may be related to LH,T.The clinical laboratory indexes of PCOS patients are chronic inflammation,abnormal endocrine and lipid metabolism.

关 键 词：多囊卵巢综合征 子宫内膜 内分泌 脂代谢 白细胞 

分 类 号：R711.75[医药卫生—妇产科学]