脂肪乳(10%)/氨基酸(15)/葡萄糖(20%)注射液致低血糖2例  

Hypoglycemia caused by lipid emulsion (10%)/amino acids(15) and glucose (20%) injection: report of 2 cases

作　　者：张小刚[1] 郭秉荣 刘菲[3] 马雅斌 Zhang Xiaogang;Guo Bingrong;Liu Fei;Ma Yabin(Department of Pharmacy,Shanghai East Hospital Affiliated to Tongji University,Shanghai 200120,China;Department of Pharmacy,the First People′s Hospital of Jinzhong,Shanxi Province,Jinzhong 030600,China;Department of Gastroenterology,Shanghai East Hospital Affiliated to Tongji University,Shanghai 200120,China)

机构地区：[1]同济大学附属东方医院药学部,上海200120 [2]山西省晋中市第一人民医院药学部,030600 [3]同济大学附属东方医院消化内科,上海200120

出　　处：《药物不良反应杂志》2019年第3期229-230,共2页Adverse Drug Reactions Journal

摘　　要：2例男性患者(例1,64岁;例2,63岁)分别因拟行胃占位性病变外科手术和消化道出血而禁食并接受肠外营养治疗。2例均在首次静脉滴注脂肪乳(10%)/氨基酸(15)/葡萄糖(20%)注射液接近结束时出现乏力、冷汗,即时血糖分别为2.2和2.1mmol/L,立即停药并静脉注射50%葡萄糖注射液40ml。约10min后,2例患者上述症状均消失,即时血糖分别为5.6和5.4mmol/L。例2次日再次静脉滴注该药近结束时上述症状复现,即时血糖为2.6mmol/L,停药并静脉注射50%葡萄糖注射液40ml,静脉滴注10%葡萄糖注射液250ml,约15min后症状消失,即时血糖为5.9mmol/L。Two male patients(patient 1, 64 years old;patient 2, 63 years old)received parenteral nutrition in fasting state due to the future surgical operation for gastric space-occupying lesions and gastrointestinal bleeding, respectively. Both of them developed fatigue and cold sweat near the end of the first IV infusion of the lipid emulsion (10%)/amino acids (15) and glucose (20%) injection. Their instant blood glucose levels were 2.2 mmol/L and 2.1 mmol/L, respectively. The symptoms disappeared about 10 minutes after the immediate discontinuation of the injection and an intravenous injection of 50% glucose injection 40 ml. And their instant blood glucose levels were 5.6 mmol/L and 5.4 mmol/L, respectively. Patient 2 developed the above symptoms again near the end of the second infusion of the drug next day and his instant blood glucose level was 2.6 mmol/L. His symptoms disappeared again after the drug withdrawal and treatment of an intravenous injection of 50% glucose 40 ml and an IV infusion of 10% glucose 250 ml for about 15 minutes. Then his instant blood glucose level was 5.9 mmol/L.

关 键 词：胃肠外营养 脂肪乳剂 静脉注射用 氨基酸类 葡萄糖 低血糖症 

分 类 号：R969[医药卫生—药理学]