老年心衰患者标准化抗心衰治疗联合法舒地尔对临床血浆脑利钠肽水平的影响观察  

Effect of Standardized Anti-heart Failure Treatment Combined with Fasudil on Clinical Plasma Brain Natriuretic Peptide Levels in Elderly Patients with Heart Failure

作　　者：魏红 杜宇[2] WEI Hong;DU Yu(The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010 China;Department of Nephrology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010 China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院医疗保健中心,内蒙古包头014010 [2]内蒙古科技大学包头医学院第一附属医院肾内科,内蒙古包头014010

出　　处：《中外医疗》2019年第15期106-108,共3页China & Foreign Medical Treatment

摘　　要：目的分析老年心衰患者标准化抗心衰治疗联合法舒地尔对临床血浆脑利钠肽水平的影响。方法回顾分析该院在2014年6月-2017年11月期间收治的70例老年心衰患者的病历资料,按照资料差异进行分组,采用标准化抗心衰治疗的为对照组,联合法舒地尔治疗的为研究组,对比两组患者的治疗效果、心功能及血浆脑利钠肽水平。结果研究组的治疗有效率为95%(38/40),明显高于对照组的70%(21/30),数据差异有统计学意义(P<0.05);研究组治疗后左室舒张末期内径为(46.53±4.14)mm,左室收缩末期内径为(37.63±4.55)mm,左室射血分数为(49.34±3.26)%,各项数据均优于对照组(P<0.05);研究组治疗后血浆脑利钠肽为(231.59±12.62)ng/L,6 min最大步行距离为(362.67±13.92)m,各项数据均优于对照组,数据差异有统计学意义(P<0.05)。结论老年心衰患者采用标准化抗心衰治疗联合法舒地尔疗效显著,可有效改善患者心功能,并降低血浆脑利钠肽水平,起到保护心肌,降低心脏负荷的作用,建议在临床中推广。Objective To analyze the effect of standardized anti-heart failure therapy combined with fasudil on clinical plasma brain natriuretic peptide levels in elderly patients with heart failure.Methods The medical records of 70 elderly patients with heart failure admitted to our hospital from June 2014 to November 2017 were reviewed.The data were divided according to the data differences.The standardized anti-heart failure treatment was used as the control group and combined with fasudil for the study group,the treatment effects,cardiac function,and plasma brain natriuretic peptide levels were compared between the two groups.Results The effective rate of the study group was 95%(38/40),which was significantly higher than that of the control group 70%(21/30).The difference was statistically significant (P<0.05).The left ventricular end-diastolic period after treatment in the study group of the inner diameter was (46.53±4.14) mm,the left ventricular end-systolic diameter was (37.63±4.55) mm,and the left ventricular ejection fraction was (49.34±3.26)%.The data were better than the control group (P<0.05).The plasma brain natriuretic peptide was (231.59±12.62) ng/L after treatment,and the maximum walking distance was (362.67±13.92) m at 6 min.All the data were better than the control group.The difference was statistically significant (P<0.05).Conclusion The treatment of senile heart failure patients with standardized anti-heart failure combined with fasudil is effective,can improve the heart function of patients,and reduce the level of plasma brain natriuretic peptide,play a role in protecting the heart muscle and reducing cardiac load.It is recommended in clinical practice and promotion.

关 键 词：老年心衰患者 标准化抗心衰治疗 法舒地尔 血浆脑利钠肽水平 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]