高龄孕妇125例孕早期甲状腺过氧化物酶抗体、游离甲状腺素与促甲状腺素激素检验结果分析  

Investigation into the determinations of thyroid peroxidase autoantibody,Free thyroxine and serum thyroid-stimulating hormone in 125 older pregnancy of the first trimester

作　　者：罗莉芸[1] LUO Liyun(Department of Clinical Laboratory of Gaoming People's Hospital,Foshan,Guangdong 528500,China)

机构地区：[1]广东省佛山市高明区人民医院检验科,528500

出　　处：《重庆医学》2019年第A01期153-155,共3页Chongqing medicine

摘　　要：目的调查分析高龄妊娠妇女孕早期的甲状腺过氧化酶抗体(TPOAb)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)等检验结果在产检中的必要性。方法选择385例孕周在8~12周的孕妇,根据年龄分为普通妊娠组(年龄小于35周岁,260例)和高龄妊娠组(年龄大于或等于35岁,125例)。采用化学发光法检测外周静脉血血清的TSH、FT4及TPOAb。结果在孕早期(T1期)高龄妊娠组孕妇TPOAb、FT4、TSH与普通妊娠组孕妇比较,差异均有统计学意义(P<0.05)。高龄妊娠组孕妇孕早期的亚临床甲减(SCH)和临床甲状腺功能减退症发生率明显高于普通妊娠组。结论联合检测TPOAb、FT4和TSH可提高妊娠合并甲状腺功能紊乱的诊断,对于保证胎儿正常发育和孕妇健康具有重要意义,尤其是对高龄孕妇具有更加重要的意义。Objective To investigate the TPOAb、FT4 and TSH in older pregnancy of the first trimester,and analyze the necessity of thyroid function test in antenatal care. Methods 385 cases of pregnant women were divided into two groups according to the age of pregnancy,Including,260 cases of general pregnancy group and 125 cases of older pregnancy group. The free thyroxin(FT4),thyroid stimulating hormone(TSH),and thyroid peroxidase antibody(TPOAb)were detected and analyzed. The results were analyzed statistically. Results During the first trimester of pregnancy,there were statistically significant differences in TSH and TPOAb between the two groups( P <0.05).The subclinical hypothyroidism and clinical hypothyroidism of the older pregnancy group were higher than those of general pregnancy group. Conclusion The determinations of the free thyroxin,thyroid stimulating hormone and thyroid peroxidase antibody in prenatal examination are very necessary and valuable .

关 键 词：亚临床甲状腺功能减退症 临床甲状腺功能减退症 妊娠早期(T1期) 抗甲状腺过氧化酶抗体 游离甲状腺素 促甲状腺素激素 

分 类 号：R581.4[医药卫生—内分泌]