嗅球成鞘细胞在脊髓损伤修复中的调控机制  

The regulatory mechanism of olfactory bulb ensheathing cells for the treatment of spinal cord injury

作　　者：胡小莉 吴艳青[2] 叶军明[1] 钟兴凤 李艺[1] 张观音生 康艳敏 HU Xiao-li;WU Yan-qing;YE Jun-ming;ZHONG Xing-feng;LI Yi;ZHANG Guanyin-sheng;KANG Yan-min(Gannan Medical University ,Jiangxi 341000;The Institute of Life Sciences,Wenzhou University,Wenzhou,Zhejiang 325035)

机构地区：[1]赣南医学院,江西赣州341000 [2]温州大学生命科学研究院,浙江温州325035

出　　处：《赣南医学院学报》2019年第6期619-626,共8页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(编号:81760230,81801233);江西省自然科学基金项目(编号:20171BAB205035);赣南医学院研究生创新项目(编号:YC2018-X0014)

摘　　要：脊髓损伤(Spinal cord injury,SCI)是一种中枢神经系统相关疾病,其治疗方法一直以来备受关注。在过去的几年中,细胞疗法已被广泛运用于SCI修复,包括多能和专能干细胞如胚胎干细胞和神经干细胞,以及许多成体干细胞,如间充质干细胞和嗅球成鞘细胞(olfactory bulb ensheathing cells,OECs)等。其中,OECs具有类干细胞特性,在神经损伤修复中具有明显的优势,其可以显著促进轴突生长和神经修复。目前已有大量研究将OECs运用于中枢神经损伤修复,尤其是SCI,包括联合生长因子或其它细胞如脂肪来源的干细胞、施万细胞及基因修饰等。本综述将深入阐述OECs在SCI修复过程中的作用和相关机制。Spinal cord injury treatment is a central nervous system-related disease,which has long been a concern. Recently,cell-based therapies have been widely used in spinal cord injury(SCI),including the use of multipotent stem cells (such as embryonic stem cells) and specialized human stem cells (such as nerves stem cells),as well as many other adult stem cells (such as mesenchymal stem cells,olfactory bulb ensheathing cells (OECs)). Among them,OECs have stem-like cell characteristics and exert obvious advantages in nerve damage repair,which significantly promote obvious axonal growth and nerve repair. A large number of studies have focused on OECs treatment for post-injury repair of central nervous system,especially SCI,which includes the joint of growth factors or other cells (such as adipose-derived stem cells,schwann cells and genetic modification). This review will clarify the role and molecular mechanism of OECs for the treatment of SCI.

关 键 词：嗅球成鞘细胞 脊髓损伤 神经再生 神经营养因子 细胞疗法 

分 类 号：R338.1[医药卫生—人体生理学]