嗜酸粒细胞与慢性阻塞性肺疾病患者激素治疗及预后关系的研究进展  

Progress on Relations of Eosinophils to Hormonal Therapy and Prognosis in Patients with Chronic Obstructive Pulmonary Disease

作　　者：付立娜 王珺[2] 蔡成森[2] 陈文靖[2] FU Lina;WANG Jun;CAI Chengsen;CHEN Wenjing(Shandong Traditional Chinese Medicine University,Jinan 250014,China;Department of Pneumology,the Second Affiliated Hospital of Shandong Traditional Chinese Medicine University,Jinan250001,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学第二附属医院呼吸科,山东济南250001

出　　处：《实用心脑肺血管病杂志》2019年第6期5-7,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：中国宋庆龄基金会呼吸疾病临床公益基金慢阻肺专项(2018MZFS-034);山东省中医药科技发展计划项目(2017-122)

摘　　要：慢性阻塞性肺疾病(COPD)是一种以气流受限为主要特征的可预防、可治疗疾病。2017慢性阻塞性肺疾病全球倡议(GOLD)指出,COPD是导致慢性病患病的主要原因,也是全球范围内四大死亡原因之一。近年研究表明,嗜酸粒细胞(EOS)可能在10%~40%的COPD患者中发挥着重要作用,但EOS是否可以指导COPD患者的激素治疗尚存在争议。本文主要综述了EOS与COPD患者激素治疗及预后的关系,以期为临床有效提高COPD患者治疗效果及改善患者预后提供参考。Chronic obstructive pulmonary disease(COPD)is mainly characterized by airflow limitation,but it is preventable and remediable. 2017 Global Initiative on Chronic Obstructive Pulmonary Disease(GOLD)pointed out that, COPD is the primary cause of chronic disease and one of the four leading causes of death all over the world. Recent studies showed that,eosinophil may play an important role in 10% to 40% patients with COPD,but role of eosinophil in guiding the hormonal therapy of COPD is still controversial. This paper mainly reviewed the relations of eosinophils to hormonal therapy and prognosis in patients with COPD,so as to provide a reference for improving the clinical therapeutic effect and prognosis in patients with COPD.

关 键 词：慢性阻塞性肺疾病 嗜酸粒细胞 嗜酸细胞趋化因子 激素治疗 预后 综述 

分 类 号：R563.9[医药卫生—呼吸系统]