基于数据挖掘的慢性阻塞性肺疾病现代中医临床用药规律探究  

Clinical Medication Rules of Modern Chinese Medicine for Chronic Obstructive Pulmonary Disease Based on Data Mining

作　　者：王仪雯 王岷[2] 王珺[2] 陈文靖[2] WANG Yiwen;WANG Min;WANG Jun;CHEN Wenjing(Shandong Traditional Chinese Medicine University,Jinan 250014,China;Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Shandong Traditional ChineseMedicine University,Jinan 250001,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学第二附属医院呼吸与危重症医学科,山东济南250001

出　　处：《实用心脑肺血管病杂志》2019年第6期68-73,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山东省中医药科技发展计划项目(2017-118);山东省医药卫生科技发展计划项目(2017WS600);中国宋庆龄基金会呼吸疾病临床研究公益基金慢阻肺专项定向委托研究项目(2018MZFS-034)

摘　　要：目的 通过数据挖掘方法探讨慢性阻塞性肺疾病(COPD)现代中医临床用药规律,为中医药治疗COPD提供理论基础和实践依据。方法 计算机检索中国知网发表于1999-01-01至2019-01-01的关于中医药治疗COPD的中文文献,采用中医传承辅助系统V2.5建立COPD处方数据库并进行用药规律挖掘。结果 (1)最终纳入107篇文献,得到115个有效处方。(2)处方中使用频次>20次的中药共14味,其中排在前5位的中药依次为茯苓、甘草、黄芪、杏仁和陈皮。(3)关联规则分析结果显示,茯苓和甘草关联系数最高;基于复杂系数熵聚类分析得到8组药物核心组合,基于无监督熵层次聚类分析得到4个新处方。结论 通过数据挖掘方法揭示出中医药治疗COPD的常用药物和药对以止咳化痰、健脾燥湿、养阴益肺、补肾纳气为主,这为现代中医治疗COPD提供了新的思路及方法。Objective To investigate the clinical medication rules of modern Chinese medicine for chronic obstructive pulmonary disease(COPD)by data mining method,to provide theoretical basis and practical evidence for Chinese medicine in treating COPD. Methods Computer was used to search Chinese literatures about Chinese medicine in treating COPD and published from 1999-01-01 to 2019-01-01,TCM Inheritance Assistance System V2.5 was used to set up the prescription database of COPD and conduct the digging for medication rules. Results (1)A total of 107 literatures were enrolled eventually,involving 115 effective prescriptions.(2)A total of 14 kinds of Chinese medicinal materials with frequency of usage over 20 times were found,thereinto the top five were poria cocos,liquorice,Astragalus membranaceus, apricot kernel and pericarpium citri reticulatae in sequence.(3)Association rules analysis results showed that,correlation coefficient between poria cocos and liquorice was the highest;entropy cluster analysis of complex coefficient found 8 groups of drug core combination,unsupervised entropy hierarchical cluster analysis found 4 new prescriptions. Conclusion Based on data mining,Chinese medicine in treating COPD mainly includes relieving cough and reducing sputum,strengthening spleen and drying dampness,nourishing Yin and lung,nourishing kidney and Qi,which provides new ideas and methods for modern Chinese medicine in treating COPD.

关 键 词：慢性阻塞性肺疾病 方剂分析 计算机辅助 数据挖掘 中医药学文献 用药规律 

分 类 号：R563.9[医药卫生—呼吸系统]