骨膜蛋白、骨桥蛋白与支气管哮喘  

Periostin, osteopontin and asthma

作　　者：许森(综述) 刘长山(审校)[1] Xu Miao;Liu Changshan(Department of Pediatrics, The Second Hospital of Tianjin Medical University, Tianjin 300211, China)

机构地区：[1]天津医科大学第二医院儿科,300211

出　　处：《国际儿科学杂志》2019年第6期396-399,共4页International Journal of Pediatrics

基　　金：天津市卫生行业重点攻关项目(16KG116).

摘　　要：骨膜蛋白、骨桥蛋白均属于细胞外基质蛋白,具有多种生物学功能。尤其在过敏性炎症疾病如哮喘中,其涉及哮喘发病机制的不同方面,如气道炎症反应和气道重塑。近年来研究表明,作为新兴的生物标志物,骨膜蛋白、骨桥蛋白在哮喘的评估和治疗中有着重要的作用。该文就骨膜蛋白、骨桥蛋白与哮喘关系的不同方面的进展进行阐述。Both periostin and osteopontin belong to extracellular matrix proteins and have various biological functions.Especially in allergic inflammatory diseases, they were involved in different aspects of the pathogenesis of asthma, such as airway inflammation and airway remodeling.Recent studies have shown that periostin and osteopontin play an important role in the assessment and treatment of asthma as emerging biomarkers.This article will elaborate on the new developments of the relationship between periostin, osteopontin and asthma.

关 键 词：骨膜蛋白 骨桥蛋白 哮喘炎症 气道重塑 治疗 

分 类 号：R562.25[医药卫生—呼吸系统]