孕妇血清维生素A、维生素E水平与子痫前期的相关性研究  

Study on the relationship between preeclampsia and elevated serum vitamin A and E levels in preg-nant women

作　　者：钟爱明[1] 戴红平[1] 宋敏荣[1] 刘伟[1] 毕桂英[1] 王丽娟 Zhong Aiming;Dai Hongping;Song Minrong;Liu Wei;Bi Guiying;Wang Lijuan(Department of Obstetrics, Shandong Rongcheng People′s Hospital, WeiHai 264300, China)

机构地区：[1]山东荣成市人民医院产科,山东威海264300

出　　处：《中国临床实用医学》2019年第3期34-37,共4页China Clinical Practical Medicine

基　　金：国家卫生计生委医药卫生科技发展课题(W2016CWSD18).

摘　　要：目的探讨孕妇血清维生素A、维生素E水平与子痫前期的相关性。方法选取2017年1月至2018年5月山东荣成市人民医院产科收治的68例子痫前期孕妇为子痫前期组,年龄(27.8±3.5)岁,年龄范围为22~39岁,另选取同期在山东荣成市人民医院产科进行产检及分娩的68例正常孕妇为健康组,年龄(27.1±3.3)岁,年龄范围为22~37岁。采用前瞻性研究,检测两组患者的维生素A与维生素E水平,并分析维生素A、维生素E水平与子痫前期的相关性。结果给予维生素临床干预后,发现子痫前期组孕妇的维生素A[(0.55±0.13)mg/L]、维生素E[(17.35±1.21)mg/L]均高于干预前[(0.21±0.08)mg/L、(2.35±0.23)mg/L],差异有统计学意义(P<0.05)。维生素A、维生素E水平与子痫前期呈负相关(r=-0.457,r=-0.316,P<0.05)。子痫前期组的新生儿窒息、胎儿窘迫、早产的发生率[4.4%(3/68)、7.4%(5/68)、8.8%(6/68)]均高于健康组[1.5%(1/68)、1.5%(1/68)、2.9%(2/68)],且子痫前期组的新生儿体质量[(3.11±0.32)kg]、新生儿阿氏Apgar评分[(7.68±1.56)分]均低于健康组[(3.79±0.56)kg、(9.36±1.29)分],差异有统计学意义(P<0.05)。结论维生素A、维生素E与子痫前期具有一定相关性,与子痫前期严重程度均呈负相关,且先于子痫前期临床症状出现前已经有了异常,是子痫前期的一项预测指标。Objective To investigate the relationship between preeclampsia and elevated serum vitamin A and E levels in pregnant women. Methods The 68 cases of pregnant women with preeclampsia who were admitted from January 2017 to May 2018 were in the preeclampsia group, aged(27.8±3.5)years old, ranging from 22 to 39 years old, at the same time, the other 60 healthy pregnant women were enrolled, aged(27.1±3.3)years old, ranging from 22 to 37 years old.The levels of vitamin A and vitamin E in the two groups were measured in a prospective study, and the correlation between the levels of vitamin A and vitamin E and preeclampsia was analyzed. Results Vitamin A[(0.55±0.13)mg/L] and vitamin E [(17.35±1.21)mg/L] of pregnant women in the preeclampsia group were higher than those before the intervention [(0.21±0.08)mg/L and(2.35±0.23)mg/L] after the clinical intervention, and the difference was statistically significant(P<0.05). Vitamin A and vitamin E levels were negatively correlated with preeclampsia(r=-0.457, r=-0.316, P<0.05). Preeclampsia group, the incidence of neonatal asphyxia, fetal distress, premature [4.4%(3/68), 7.4%(5/68), 8.8%(6/68)] were higher than in healthy group [1.5%(1/68), 1.5%(1/68), 2.9%(2/68)], and preeclampsia group of neonatal body quality [(3.11±0.32)kg], neonatal Apgar score(7.68±1.56)were lower than healthy group [(3.79±0.56)kg,(9.36±1.29)]. The difference was statistically significant(P<0.05). Conclusion Vitamin A and vitamin E are correlated with preeclampsia, negatively correlated with the severity of preeclampsia, and abnormal before the clinical symptoms of preeclampsia, which is a predictor of preeclampsia.

关 键 词：维生素A 维生素E 子痫前期 

分 类 号：R714[医药卫生—妇产科学]