急性肾盂肾炎患者感染病原菌与CRP及 PCT水平变化的相关性研究  

The correlation of pathogen distribution and the changes of CRP and PCT levels in acute pyelonephritis patients

作　　者：滕旭升 盛孝燕[1] 丁颖威 程江华[1] 许旭春[1] TENG Xu-sheng;SHENG Xiao-yan;DING Ying-wei;CHENG Jiang-hua;XU Xu-chun(ICU of Accident and Emergency , Jinhua Central Hospital, Jinhua, Zhejiang 321000 , China)

机构地区：[1]金华市中心医院急诊重症监护室

出　　处：《中国预防医学杂志》2019年第6期533-536,共4页Chinese Preventive Medicine

摘　　要：目的了解急性肾盂肾炎患者感染病原菌与C反应蛋白(C-reactive protein,CRP),降钙素原(procalcitonin,PCT)水平变化的相关性。方法选取2016年12月至2018年1月金华市中心医院治疗的急性肾盂肾炎患者105例,分为早期组(n=63)和晚期组(n=42),分别检测血清CRP、PCT水平变化,并取患者尿样进行病原菌分离培养及药敏试验。结果治疗前后,两组患者血清CRP、PCT表达水平差异无统计学意义(P>0.05);治疗后两组CRP、PCT表达水平均较治疗前降低(P<0.05);检出病原菌阳性65例,共分离到77株病原菌,以革兰阴性菌为主,其中大肠埃希菌占比最高,占31.17%。结论 CRP、PCT表达水平可用于对急性肾盂肾炎患者疾病发生及发展进程的监测。Objective To explore the correlation of pathogen distribution and the changes of CRP and PCT levels in acute pyelonephritis(APN) patients with septic shock. Methods 105 APN patients with septic shock in Jinhua Central Hospital between December 2016 and January 2018 were enrolled and divided into early stage(n=63) and late stage(n=42).Blood samples were collected for the detection of serum CRP and PCT, urine samples were also collected for pathogen culture and drug susceptibility test. Results There were no significant differences in serum levels of CRP and PCT between the two groups before and after the treatment(P>0.05).The levels of CRP and PCT declined significantly in the two groups after the treatment(P<0.05).65 urine samples were pathogen culture positive and total 77 strains of bacteria were isolated with Gram-negative bacteria predominant and 31.17% were E.coli. Conclusions The change of serum levels of CRP and PCT can be used as a monitor for disease occurrence and progression in APN patients.

关 键 词：急性肾盂肾炎 感染菌 耐药性 C反应蛋白 降钙素原 大肠埃希菌 

分 类 号：R453[医药卫生—治疗学]