中药血清药物化学的应用现状概述  

Review on the Application of Serum Pharmacochemistry of Traditional Chinese Medicine

作　　者：张雯霞 冯敏 苗雨露 张文智 倪艳[2] ZHANG Wenxia;FENG Min;MIAO Yulu;ZHANG Wenzhi;NI Yan(Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China;Shanxi Academy of Traditional Chinese Medicine, Taiyuan 030012, China)

机构地区：[1]山西中医药大学,山西太原030619 [2]山西省中医药研究院,山西太原030012

出　　处：《药物评价研究》2019年第7期1448-1453,共6页Drug Evaluation Research

基　　金：山西省重点研发项目(项目编号:201603D321028)

摘　　要：中药血清药物化学是通过对实验动物口服给药后的含药血清进行分析,对药效物质基础及复方配伍机制进行快速筛选的一项新型技术,在中药质量控制、中药炮制研究等领域都发挥重要作用。随着不断的发展创新,将其与血清药理学、药动学等学科相互融合,为中药及复方的研究提供了更加完善的手段。对中药血清药物化学的主要技术手段、应用研究及其与一些学科的联合使用现状进行综述,为中药血清药物化学的发展提供新的研究思路。Serum pharmacochemistry of traditional Chinese medicine (TCM) is a new technique for rapid screening of effective material basis and compound compatibility mechanism by analyzing the serum containing drugs after oral administration in experimental animals.It plays an important role in the quality control of traditional Chinese medicine,the processing of traditional Chinese medicine and other fields.With the continuous development and innovation,it is integrated with serum pharmacology,pharmacokinetics and other disciplines,which provides a more perfect means for the study of traditional Chinese medicine and compound prescription.In this paper,the main technical means and applied research of serum pharmacochemistry of traditional Chinese medicine and its combined use with some disciplines are reviewed,which provides a new research idea for the development of serum pharmacochemistry of traditional Chinese medicine.With the continuous development and innovation,it is integrated with serum pharmacology,pharmacokinetics and other disciplines,which provides a more perfect means for the study of traditional Chinese medicine and compound prescription.In this paper,the main technical means and applied research of serum pharmacochemistry of traditional Chinese medicine and its combined use with some disciplines are reviewed,which provides a new research idea for the development of serum pharmacochemistry of traditional Chinese medicine.

关 键 词：血清药物化学 血清药理学 药动学 谱效关系 网络药理学 中医方证代谢组学 

分 类 号：R284[医药卫生—中药学]