益气活血化痰方对经皮冠状动脉介入术后慢血流患者的干预作用  

Effect of Yiqi Huoxue Huatan Recipe on Patients with Slow Blood Flow After Percutaneous Coronary Intervention

作　　者：黄宇 王肖龙[1] 郭炜[1] 关敬树[2] 薛金贵[1] 陈铁军[1] 苏立杰[1] 赵汉君 HUANG Yu;WANG Xiao-long;GUO Wei;GUAN Jing-shu;XUE Jin-gui;CHEN Tie-jun;SU Li-jie;ZHAO Han-jun(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China;Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200431,China;Gongli Hospital of Pudong New Area,Shanghai,200135,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海中医药大学附属曙光医院宝山分院,上海200431 [3]上海市浦东新区公利医院,上海200135

出　　处：《南京中医药大学学报》2019年第4期387-390,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：上海市卫计委临床专项(201840309)

摘　　要：目的观察益气活血化痰方对经皮冠状动脉介入术(PCI)后慢血流患者冠状动脉血流和主要临床症状的改善作用.方法将44例患者随机分为治疗组和对照组各22例.所有患者在术后24 h起每日给予常规冠心病二级预防药物(双重抗血小板药物、他汀类药物、ACEI/ARB类药物和β受体阻滞剂)治疗,治疗组在此治疗基础上加服益气活血化痰中药,每日1剂.治疗3月后,观察2组治疗前后的冠状动脉血流(TIMI血流分级和校正的TIMI帧数)变化,中医证候积分和主要临床症状(心绞痛发生次数、持续时间、硝酸甘油用量)的改善情况.结果治疗组治疗后TIMI血流分级和校正的TIMI帧数有显著改变(P<0.05~0.01);治疗组治疗前后中医证候积分显著降低(P<0.01),主要临床症状显著改善(P<0.01),改善程度明显优于对照组(P<0.05~0.01).结论益气活血化痰方可改善冠状动脉介入术后慢血流患者冠状动脉血流和主要临床症状.OBJECTIVE To observe the effect of Yiqi Huoxue Huayu recipe on coronary blood flow and main clinical symptoms in patients with slow blood flow after percutaneous coronary intervention (PCI). METHODS 44 patients were randomly divided into treatment group and control group, 22 cases in each group. All patients received daily secondary prevention drugs for coronary heart disease (double antiplatelet drugs, statins, ACEI/ARB drugs and beta blockers) from 24 hours after surgery. On the basis of this treatment, The treatment group was given Yiqi Huoxue Huatan recipe, one dose a day. After 3 months of treatment, the changes of coronary blood flow (TIMI blood flow grading and corrected TIMI frame) before and after treatment, TCM syndrome scores and main clinical symptoms (number of angina pectoris, duration, nitroglycerin dosage) were observed. RESULTS The TIMI blood flow grading and corrected TIMI frame number in the treatment group were significantly changed (P<0.05,P<0.01). The TCM syndrome scores in the treatment group were significantly lower before and after treatment (P<0.05 ,P<0.01). The main clinical symptoms were significantly improved (P<0.01), the degree of improvement was significantly better than the control group (P<0.01). CONCLUSION Yiqi Huoxue Huatan recipe can improve coronary blood flow and main clinical symptoms in patients with slow blood flow after PCI.

关 键 词：益气活血化痰方 冠状动脉慢血流 临床症状 

分 类 号：R256.2[医药卫生—中医内科学]