慢性阻塞性肺疾病患者血清IL-33及受体ST2水平的变化及分析  

Expression and implication of human interleukin-33 and the receptor ST2 in chronic obstructive pulmonary disease

作　　者：程丹[1] 郑志水[1] 丁续红[1] CHENG Dan;ZHENG Zhi-shui;DING Xu-hong(Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)

机构地区：[1]武汉大学人民医院呼吸与危重症医学科

出　　处：《临床肺科杂志》2019年第8期1363-1365,共3页Journal of Clinical Pulmonary Medicine

基　　金：国家自然科学基金项目(No 81600023);国家留学基金资助(No 201806275100)

摘　　要：目的探讨白细胞介素33(IL-33)及受体ST2在慢性阻塞性肺疾病发病机制中的作用。方法收集慢性阻塞性肺疾病(简称慢阻肺)患者50例及健康对照者30例,用ELISA法检测入组人群外周血中IL-33及其受体ST2的含量,并分析IL-33的表达水平与其受体ST2以及气流受限之间的相关性。结果慢阻肺患者外周血血清中IL-33[(311.21±16.21)pg/mL]及受体ST2的含量[(3.069±0.17)pg/mL]均明显高于健康对照者,差异有统计学意义(P<0.05)。慢阻肺患者外周血血清中IL-33水平与其受体ST2含量呈正相关关系(r=0.336,P=0.02),与肺功能FEV1/FVC呈负相关(r=-0.455,P=0.001)。结论IL-33在慢阻肺发病过程中具有促进炎症反应的作用,此过程可能与其受体ST2有关。Objective To investigate the possible roles of IL-33 and the receptor ST2 in chronic obstructive pulmonary disease (COPD).Methods 50 patients with COPD and 30 healthy subjects were recruited.The concentrations of IL-33 and ST2 in serum were measured by enzyme-linked immunosorbent assay (ELISA).The correlations among IL-33,ST2 and lung function test were performed.Results The serum level of IL-33 [(311.21±16.21) pg/mL] and ST2 [(3.069±0.17)ng/mL] was significantly higher in COPD patients than in healthy subjects ( P< 0.05).Moreover,the serum IL-33 level in COPD was positively correlated with the serum ST2 level ( r=0.336,P =0.02).The serum IL-33 level in COPD was negatively correlated with FEV 1/FVC ( r=-0.455,P =0.001).Conclusion IL-33 and ST2 may be involved in the pathogenesis of airway inflammation in COPD.

关 键 词：慢性阻塞性肺疾病 IL-33 ST2 

分 类 号：R563.9[医药卫生—呼吸系统]