载脂蛋白B/载脂蛋白A-1值对冠心病患者心血管事件的预测价值  

Value of apolipoprotein B/apolipoprotein A-1 in predicting cardiovascular events in patients with coronary heart disease

作　　者：王田园 蔡安季[1] 李钢[1] 郝亚军 刘诗诗 WANG Tian-yuan;CAI An-ji;LI Gang;HAO Ya-jun;LIU Shi-shi(Laboratory Department, Nanshan People's Hospital,Shenzhen 518052, China)

机构地区：[1]广东省深圳市南山区人民医院检验科

出　　处：《广东医科大学学报》2019年第4期464-467,共4页Journal of Guangdong Medical University

基　　金：深圳市知识创新计划基金(No.JCYJ20150402152130177)

摘　　要：目的探讨载脂蛋白B(apoB)和载脂蛋白A-1(apoA-1)对冠心病患者心血管事件的预测价值。方法回顾性分析本院2016年5月至2018年1月200例冠心病患者,依照患者行经皮冠状动脉介入术后1 a有无不良心血管事件(MACE)发生分为MACE组(59例)和非MACE组(141例),分析apoB/apoA-1与MACE发生的关系,并依据apoB/apoA-1正常参考范围值将结果≥1的患者纳入高比值组,<1的患者纳入低比值组,比较两组MACE的发生情况。结果 MACE组患者的apoB水平和apoB/apoA-1值明显高于非MACE组,而apoA-1水平则低于非MACE组,差异有统计学意义(P<0.01)。apoB/apoA-1值预测MACE发生的ROC曲线下面积AUC为0.895,大于apoB(0.623)和apoA-1(0.662),差异有统计学意义(P<0.05)。apoB/apoA-1高比值组患者MACE发生率为43.48%,高于低比值组的22.14%,差异有统计学意义(P<0.05)。结论 apoB/apoA-1对冠心病患者心血管事件的预测价值较高,监测apoB/apoA-1的动态变化有利于早期预测与干预心血管事件。Objective To investigate the value of apolipoprotein B (apoB)/ apolipoprotein A-1 (apoA-1) in predicting cardiovascular events in patients with coronary heart disease. Methods The clinical data of 200 patients with coronary heart disease in a hospital from May 2016 to January 2018 were retrospectively analyzed. They were divided into MACE group (n=59) and non-MACE group (n=141) according to the presence or absence of major adverse cardiovascular events (MACE) within 1 year after the percutaneous coronary intervention. The relationship between apoB/apoA-1 and the incidence of MACE was analyzed. According to the value of apoB/apoA-1 normal reference range, patients with the results ≥ 1 were included in High-Ratio Group while patients with the results <1 were included in Low-Ratio Group. The incidence of MACE in the two groups was compared. Results The apoB level in the MACE Group was significantly higher than that in the Non- MACE Group while the apoA-1 level in the MACE Group was lower than that in the Non-MACE Group, and the difference was statistically significant (P<0.01). The area under the curve (AUC) for the prediction of the incidence of MACE by apoB/apoA-1 was 0.895, which was higher than that by the apoB (AUC=0.623) and apoA-1 (AUC=0.662), and the differences were statistically significant (P<0.05). The incidence of MACE in the High-Ratio Group was higher than that in the Low-Ratio Group (43.48% vs 22.14%), and the differences were statistically significant (P<0.01). Conclusion ApoB/apoA-1 has relatively high value in the prediction of cardiovascular events in patients with coronary heart disease. Monitoring the dynamic changes of apoB/apoA-1 can be beneficial to early prediction and intervention of cardiovascular events.

关 键 词：冠心病 载脂蛋白B 载脂蛋白A-1 

分 类 号：R541.4[医药卫生—心血管疾病]