血清生物素、维生素B12及叶酸对过早白发症的价值  

Roles of serum biotin,vitamin B12 and folic acid in premature white hair disease

作　　者：马铭 任汉强[1] MA Ming;REN Hanqiang(Department of Endocrine,the Sixth Hospital of Wuhan,Jianghan University,Wuhan 430015, Hubei,China)

机构地区：[1]江汉大学附属武汉市第六医院内分泌科

出　　处：《检验医学》2019年第7期622-625,共4页Laboratory Medicine

摘　　要：目的探讨血清生物素、维生素B12(Vit B12)、叶酸(FA)对过早白发症的价值。方法选取过早白发症患者80例,以体检健康者80名作为正常对照组。收集2个组的一般资料[性别、年龄、体质量指数(BMI)、总蛋白(TP)、白蛋白(Alb)、白蛋白/球蛋白(A/G)比值、空腹血糖、总胆固醇(TC)、总胆红素(TB)、碱性磷酸酶(ALP)、钙、磷等]并检测血清生物素、Vit B12和FA。对过早白发症患者进行老龄化严重程度评分(GSS),比较过早白发症患者不同GSS组Vit B12缺乏症和FA缺乏症患者比例的差异。结果过早白发症组与正常对照组之间性别、年龄、BMI、TP、Alb、A/G比值、空腹血糖、TC、TB、ALP、钙、磷水平差异均无统计学意义(P>0.05)。过早白发症组血清生物素、Vit B12和FA水平均明显低于正常对照组(P<0.05)。80例过早白发症患者中GSS轻度30例、中度42例、重度8例。GSS轻度组、中度组和重度组中Vit B12缺乏症患者分别为10例(33.33%)、22例(52.38%)和8例(100.00%),FA缺乏症患者分别为4例(13.33%)、13例(30.95%)和4例(50.00%)。Vit B12缺乏症、FA缺乏症比例随过早白发症患者GSS的升高而升高。不同GSS组Vit B12缺乏症比例差异有统计学意义(P<0.05),而FA缺乏症差异无统计学意义(P>0.05)。结论血清生物素、Vit B12及FA水平与过早白发症有一定的关系。Objective To investigate the roles of serum biotin,vitamin B12(Vit B12)and folic acid(FA)in premature white hair disease.Methods A total of 80 patients with premature white hair disease and 80 healthy subjects(healthy control group)were enrolled.Their general data[sex,age,body mass index(BMI),total protein(TP),albumin(Alb),albumin/globulin(A/G)ratio,fasting blood glucose,total cholesterol(TC),total bilirubin(TB),alkaline phosphatase(ALP),calcium,phosphorus and so on]were collected,and serum biotin,Vit B12 and FA were determined.Graying severity score(GSS)was used for evaluating patients with premature white hair disease,and the difference of Vit B12 and FA deficiency proportions in different GSS groups was compared.Results There was no statistical significance in sex,age,BMI,TP,Alb,A/G ratio,fasting blood glucose,TC,TB,ALP,calcium and phosphorus levels between the 2 groups(P>0.05).The levels of biotin,Vit B12 and FA in premature white hair disease group were lower than those in healthy control group(P<0.05).Among the 80 patients with premature white hair disease,there were 30 cases of GSS mild,42 cases of GSS moderate and 8 cases of GSS severe.There were 10(33.33%),22(52.38%)and 8(100.00%)cases of Vit B12 deficiency in GSS mild,moderate and severe groups,respectively,and there were 4(13.33%),13(30.95%)and 4(50.00%)cases of FA deficiency,respectively.The proportions of Vit B12 deficiency and FA deficiency increased with the increase of GSS in patients with premature white hair disease.There was statistical significance for the proportion of Vit B12 deficiency among different GSS groups(P<0.05),and there was no statistical significance for the proportion of FA deficiency(P>0.05).Conclusions Serum biotin,Vit B12 and FA are related to premature white hair disease.

关 键 词：生物素 维生素B12 叶酸 过早白发症 

分 类 号：R446.1[医药卫生—诊断学]