聚偏氟乙烯微孔滤膜-聚多巴胺-氧化石墨烯固相萃取结合离子迁移谱快速检测尿液中的麻黄碱  

Rapid Detection of Ephedrine in Urine by Ion Mobility Spectrometry with Polyvinylidene Fluoride Microporous Membrane-Polydopamine-Graphene Oxide Solid Phase Extraction

作　　者：柴常伟 刘迪[1] 崔毅轩 管宇珊 庞羽 王子晗 蒋晔[1] CHAI Chang-wei;LIU Di;CUI Yi-xuan;GUAN Yu-shan;PANG Yu;WANG Zi-han;JIANG Ye(Pharmacy College,Hebei Medical University,Shijiazhuang050017,China)

机构地区：[1]河北医科大学药学院

出　　处：《分析测试学报》2019年第7期798-804,共7页Journal of Instrumental Analysis

基　　金：大学生创新性实验项目(USIP2018112)

摘　　要：建立了新型聚偏氟乙烯微孔滤膜-聚多巴胺-氧化石墨烯固相萃取结合便携式高分辨离子迁移谱对尿液中的麻黄碱进行快速检测的方法。通过对新型固相萃取膜的制备过程、吸附、洗脱过程进行优化,可对尿液中麻黄碱实现5min吸附、10min洗脱、30ms进样的快速检测。结果显示,麻黄碱在0.124~6.129μg/mL质量浓度范围内的线性良好,检出限为9.60ng/mL,方法的回收率为91.0%~113%。该方法能够快速地完成对尿液中麻黄碱的检测,为药驾在线检测和现场监察提供了有效手段。A novel method was established for the rapid detection of ephedrine in urine by portable high-resolution ion mobility spectrometry with poly-vinylidene fluoride microporous membrane-polydopamine-graphene oxide solid phase extraction.The new type of solid phase extraction membrane could realize a 5 min of rapid adsorption,a 10 min of elution and a 30 ms of injection detection for ephedrine by optimizing preparation process,adsorption and elution process.The results showed that good linearity was found from 0.124 μg/mL to 6.129 μg/mL for ephedrine with a detection limit of 9.60 ng/mL,and the recoveries ranged from 91.0 % to 113 %.The method could be applied in the rapid detection of ephedrine in urine,and provide an effective means for on-line detection and on-site monitoring of driving under the inference of drugs.

关 键 词：聚偏氟乙烯 氧化石墨烯 固相萃取 便携式高分辨离子迁移谱 麻黄碱 尿样 药驾 

分 类 号：O657.7[理学—分析化学]