医用Ti-6Al-4V合金表面氟硅烷超疏水涂层的制备及生物学性能  

Preparation and Biological Properties of the Fluoroalkyl Silane Superhydrophobic Coatings on Biomedical Ti-6Al-4V Alloy

作　　者：姜久仰[1] 刘宏宇[1] 徐吉林[2] 张鹏[2] 张铁娃[1] Jiang Jiuyang;Liu Hongyu;Xu Jilin;Zhang Peng;Zhang Tiewa(The First Affiliated Hospital of Harbin Medical University, Harbin 150001,China;Nanchang Hangkong University, Nanchang 330063,China)

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001 [2]南昌航空大学,江西南昌330063

出　　处：《稀有金属材料与工程》2019年第6期1884-1891,共8页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(51101085);江西省科技计划(20151BBG70039);黑龙江省卫生计生委科研项目(2016-023)

摘　　要：采用微弧氧化技术和氟硅烷修饰在医用Ti-6Al-4V合金表面构建超疏水涂层。考察微弧氧化电压对涂层表面形貌及粗糙度的影响,分析微弧氧化涂层和超疏水涂层的相组成及元素化学状态,以探讨超疏水表面的形成机制。初步研究了超疏水试样的细胞毒性和抗菌性能。结果表明,随着微弧氧化电压的增加,涂层的表面粗糙度增大,而显微结构均匀性在440 V最佳。经疏水处理后,试样的表面粗糙度较微弧氧化试样有所下降,而接触角随着电压的增加而先增大后减小,在440 V时获得最大值154.9°。微弧氧化涂层主要由锐钛矿及少量金红石TiO2相组成,并含有大量的–OH和一些磷的化合物,而超疏水试样表面存在大量的CF3、CF2和Si-O基团。全氟辛基三氯硅烷通过水解和脱水反应将氟硅烷嫁接于微弧氧化涂层上而形成超疏水表面。超疏水试样属于1级无毒材料,其细胞增殖率与Ti-6Al-4V合金无显著差异。此外,超疏水试样还具有一定的抗菌性,相对微弧氧化试样,其抗菌率可达93.03%。The superhydrophobic coatings were prepared on the surface of biomedical Ti-6Al-V alloy by micro-arc oxidation(MAO)and surface modification of fluoroalkyl silane.The effect of voltages on surface morphologies and roughness of the coatings was investigated,and the phase composition and element chemical state of the MAO and hydrophobic treated samples were analyzed to discuss the formation mechanism of the superhydrophobic coating.At the same time,the cytotoxicity and antibacterial property of the superhydrophobic samples were also preliminarily evaluated.The results show that the surface roughness of the coatings increases with increasing the voltages,and the microstructure uniformity of the coatings is optimum at 440 V.After superhydrophobic treatment,the surface roughness of samples decreases slightly compared to that of the MAO samples,and the contact angles of the samples increase first,and then decrease with increasing the voltages,reaching the maximum value of 154.9°at 440 V.The MAO coating is mainly composed of anatase TiO2 phase and a little rutile TiO2 phase with a large number of–OH and some phosphorus compounds.While the surface of the superhydrophobic coating contains a large number of CF3,CF2 and Si-O groups.The fluoroalkyl silane is grafted onto the MAO coating through the hydrolytic reaction and dehydration reaction to form the superhydrophobic surface.The superhydrophobic sample belongs to Class 1 non-toxic material,and the cell viability of the superhydrophobic sample has no significant difference from that of Ti-6Al-4V alloy.Moreover,the superhydrophobic sample also has certain antibacterial property,and the antibacterial rate can be up to 93.03%compared to that of the MAO treated sample.

关 键 词：医用Ti-6Al-4V合金 微弧氧化 超疏水涂层 细胞毒性 抗菌性 

分 类 号：TG146.23[一般工业技术—材料科学与工程]