纯钛表面载骨碎补提取物涂层的制备与性能  

Preparation and Property of Coatings Carrying Extract of Rhizoma Drynariae on the Surface of Pure Titanium

作　　者：彭书浩 李慕勤[1] 王晶彦[1] 田钦文 Peng Shuhao;Li Muqin;Wang Jingyan;Tian Qinwen(Key Laboratory of Biomedical Materials of Heilongjiang Province, Jiamusi University, Jiamusi 154007,China)

机构地区：[1]佳木斯大学黑龙江省高校生物医学材料重点实验室

出　　处：《稀有金属材料与工程》2019年第6期1921-1928,共8页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(31370979)

摘　　要：为了提高纯Ti的生物活性和抗感染性,采用微弧氧化(UMAO)制备多孔涂层,并以植酸(PA)为偶联剂将骨碎补提取物(ERD)载入多孔涂层中,并分析涂层结构、形貌及性能。结果表明,随着ERD浓度的提高,纳米颗粒增多,有PO43-,P2O74-和O=P-O-生成;载药12.5 g/L的膜层的摩擦系数较低,为亲水涂层;相对于未载药涂层,载药膜层的电位提高了0.33~0.45 V,自腐蚀电流降低1个数量级;模拟体液浸泡有羟基磷灰石(HA)生成。纯钛表面通过超声微弧氧化,植酸偶联载药涂层的耐蚀性、结合力和生物活性均有提高。To improve the bioactivity of surface of titanium and reduce infection rate of implantation,porous coatings were prepared by ultrasonic micro arc oxidation(UMAO)and phytic-acid-coupled extract of rhizoma drynariae(ERD)was loaded in the coatings.Besides,the structure,surface morphology and performance of the coatings were investigated.The results indicate that nano particles of drug loading increase in number with the increasing of ERD concentration.The surface of the coatings produce PO43-,P2O74-and O=P-O-.The friction coefficient of the coating carrying ERD with concentration of 12.5 g/L is lower.Also,this coating is hydrophilic.The potential increases by 0.33~0.45 V and self-corrosion current decreases by an order of magnitude for the coatings carrying ERD.The coatings produce HA after soaking in SBF for 7 d.In conclusion,the corrosion resistance,binding force and bioactivity are improved by drug loading coupled with phytic acid after MAO on the pure titanium.

关 键 词：纯钛 微弧氧化 骨碎补提取物 植酸 骨修复材料 

分 类 号：TG146.23[一般工业技术—材料科学与工程]