静脉注射18F-FDG注射液后冲洗注射器对残留剂量及肝脏标准化摄取值的影响  

Impact of syringe saline flush after injection of 18F-FDG on residual dose and standardized uptake value of liver

作　　者：郝振亮 王俊清[2] 任超[2] 赵晓斌[3] HAO Zhenliang;WANG Junqing;REN Chao;ZHAO Xiaobin(Department of Radiology,Civil Aviation General Hospital,Beijing 100123,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Nuclear Medicine,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]民航总医院放射科,北京100123 [2]中国医学科学院北京协和医院核医学科,北京100730 [3]首都医科大学附属北京天坛医院核医学科,北京100070

出　　处：《中国医学影像技术》2019年第7期1091-1094,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81527805)

摘　　要：目的探讨PET/CT检查时静脉注射18F-FDG注射液后冲洗注射器对放射性药物残留剂量以及肝脏标准化摄取值(SUV)的影响。方法收集接受PET/CT检查的50例患者,根据注药方式分为对照组(n=25)和实验组(n=25)。采用23G头皮针建立静脉通路,注射18F-FDG注射液后,对照组直接用5 ml生理盐水冲洗管道;实验组先用1 ml生理盐水冲洗管道,然后用2 ml生理盐水冲洗注射器,最后用剩余2 ml再次冲洗管道。比较2组间18F-FDG注射后残留剂量以及肝脏SUV平均值(SUV mean)和SUV最大值(SUVmax)的差异。结果实验组总残留剂量[(0.22±0.08)mCi]、注射器内残留剂量[(0.19±0.07)mCi]和静脉通道内残留剂量[(0.03±0.02)mCi]均小于对照组(P均<0.01)。实验组与对照组肝脏3个不同层面(第二肝门层面、门静脉左支层面、第一肝门层面)的SUV mean 和SUVmax差异均无统计学意义(P均>0.05)。结论冲洗注射器能减少18F-FDG注射液残留量。注射器内少量放射性药物残留尚不足以引起肝脏SUV变化,但进一步规范18F-FDG注射操作流程仍属必要。Objective To investigate the impact of saline flush for syringe after 18F-FDG injection on the residual dose of 18F-FDG and the standardized uptake value (SUV) of liver during PET/CT examination.Methods A total of 50 patients who underwent PET/CT examination were enrolled and divided into control group (n=25) and experimental group (n=25) according to different injection methods.Device system of the vein passage was established with 23 gauge scalp needle.In control group,the intravenous line was directly flushed with 5 ml physiological saline after 18F-FDG injection,while in experimental group,firstly the intravenous line was flushed with 1 ml saline,then the syringe was flushed with 2 ml saline,finally the intravenous line was flushed again with the residual 2 ml saline.The residual dose of 18F-FDG and SUV mean and SUV max of liver were compared between the two groups.Results The total residual dose ([0.22±0.08]mCi),syringe residual dose ([0.19±0.07]mCi) and intravenous channel residual dose ([0.03±0.02]mCi) in the experimental group were all lower than those in control group (all P<0.01).There was no significant difference of SUV mean nor SUV max between experimental group and control group at 3 different levels of the liver (level of the second liver porta,level of the left portal vein and level of the first liver porta,all P>0.05).Conclusion Flushing the syringe can reduce residual dose of 18F-FDG injection.A small amount of radiopharmaceuticals retention in the syringe may not affect SUV for liver,but further standardization of the operation process of 18F-FDG injection is still necessary.

关 键 词：氟脱氧葡萄糖F18 注射器 残留量 标准化摄取值 正电子发射体层摄影术 

分 类 号：R817[医药卫生—影像医学与核医学]