三种瓜环与多巴胺的分子包结行为研究  

Inclusion Behavior between Three Kind of Cucurbit [n] urils and Dopamine

作　　者：孟铁宏[1] 李春荣[1] 胡先运[1] 姜艳萍[1] 王恒[1] 肖昕[2] MENG Tie-hong;LI Chun-rong;HU Xian-yun;JIANG Yan-ping;WANG Heng;XIAO Xin(Public Course Teaching Department, Qiannan Medical College for Nationalities, Duyun 558000,China;Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,Guizhou University,Guiyang 550025,China)

机构地区：[1]黔南民族医学高等专科学校公共课教学部,贵州都匀558000 [2]贵州大学贵州省大环化学及超分子化学重点实验室,贵州贵阳550025

出　　处：《化学试剂》2019年第7期729-733,共5页Chemical Reagents

基　　金：国家自然科学基金项目(21861011);黔南民族医学高等专科学校基金项目(QNYZ201605,QNYZ201706);黔南州社会发展资助项目(黔南州科合社字[2016]1号,黔南州科合社字[2017]19号)

摘　　要：为了开发多巴胺类药物在以瓜环为载体的超分子药物包合物方面的应用,选取了3种具有不同空腔大小的瓜环:对称四甲基六元瓜环(TMeQ[6])、七元瓜环(Q[7])、八元瓜环(Q[8]),利用核磁共振氢谱、MALDI-TOF质谱以及紫外吸收光谱等手段探究了3种瓜环与药物分子多巴胺(DA)的超分子包结行为。结果表明,DA只位于TMeQ[6]的端口,与空腔较小的TMeQ[6]形成端口作用,而进入了空腔相对更大的瓜环Q[7]、Q[8]的内腔形成了主客体超分子药物包合物,为利用瓜环作为药物分子传递、缓释的载体提供了一定的理论依据。In order to develop the application of dopamine( DA) in supramolecular drug inclusion complexes,three kinds of cucurbit[n]urils including TMeQ[6],Q[7] and Q[8] were employed as hosts,the supramolecular self-assembly between these cucurbit[n]urils with dopamine guest have been investigated by1 HNMR spectroscopy,UV spectroscopy and MALDI-TOF mass spectrometry.The results revealed that the DA was located the portal of the TMeQ[6],whereas the whole DA molecule were located inside the cavity of the Q[7]or Q[8]host,forming inclusion complexes.This provides an evidence for the use of cucurbit[n]urils as carriers for drug delivery and release.

关 键 词：对称四甲基六元瓜环 七元瓜环 八元瓜环 多巴胺 包结 

分 类 号：O641.3[理学—物理化学]