磺酸功能化胆碱的制备及其在吲唑并[2,1-b]酞嗪-1,6,11-三酮合成中的应用  

Preparation of Sulfonic Acid Functionalized Choline and Application on Synthesis of Indazolo [2,1-b]phthalazine-1,6,11-triones

作　　者：王英磊[1] 叶红勇[1] 杜朝军[1] 张群安[1] WANG Ying-lei;YE Hong-yong;DU Chao-jun;ZHANG Qun-an(School of Biological and Chemical Engineering, Nanyang Institute of Technology,Nanyang 473004,China)

机构地区：[1]南阳理工学院生物与化学工程学院

出　　处：《化学试剂》2019年第7期754-758,共5页Chemical Reagents

基　　金：河南省科技攻关项目(182102310601);河南省高等学校重点科研项目(17B150007)

摘　　要：以氯化胆碱为主要原料,制备了一种环境友好型催化剂--磺酸功能化胆碱。在磺酸功能化胆碱用量10%、反应温度80℃的条件下,不同取代基芳香醛与5,5-二甲基-1,3-环己二酮(或1,3-环己二酮)和邻苯二甲酰肼在水相中顺利完成3组分“一锅煮”反应,以83%~95%的产率合成了一系列目标化合物。该方法反应条件温和,底物普适性和官能团兼容性优良,后处理操作简便,催化剂重复利用6次后仍保持较高的催化活性,符合绿色化学与清洁生产的发展理念。The environment-friendly catalyst of sulfonic acid functionalized choline was prepared with choline chloride as the main raw material.Under the conditions of 10% of sulfonic acid functionalized choline dosage,80 ℃ of reaction temperature,the one-pot three-component reaction of various aromatic aldehyde,5,5-dimethyl-1,3-cyclohexanedione( or 1,3-cyclohexanedione) and phthalhydrazide were completed successfully in water,for the synthesis of a series target compounds in yield of 83%~ 95%.Several advantages such as mild reaction conditions,excellent substrate universality and functional group compatibility,simple post-treatment operation were offered and the catalyst still retains high activity after six times of recycling,which meet the development concept of green chemistry and cleaner production.

关 键 词：磺酸功能化胆碱 吲唑并[2 1-b]酞嗪-1 6 11-三酮 多组分反应 回收使用 

分 类 号：TQ612.6[化学工程—精细化工]