细胞外囊泡对肿瘤生物学特性的影响研究进展  

Advance in research on the effects of extracellular vesicles on the biological characteristics of tumor

作　　者：贺玲 张小燕[2] 杨雅芝[3] 李剑[3] HE Ling;ZHANG Xiaoyan;YANG Yazhi;LI Jian(Clinical Department, Jiangxi Health Vocational College, Jiangxi Province, Nanchang 330052, China;Medical College of Nanchang University, Jiangxi Province, Nanchang 330006, China;Key Blood Laboratory, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, Nanchang 330052, China)

机构地区：[1]江西卫生职业学院临床系,江西南昌330052 [2]南昌大学医学院,江西南昌330006 [3]南昌大学第二附属医院血液重点实验室,江西南昌330052

出　　处：《中国医药导报》2019年第19期62-65,共4页China Medical Herald

基　　金：江西省教育厅科学技术研究项目(GJJ161453)

摘　　要：肿瘤的生长、侵袭和转移依赖于肿瘤细胞与其所处微环境中基质细胞的“交叉对话”,这种“交叉对话”主要涉及这两种细胞的可溶因子的分泌、膜包囊颗粒的释放以及细胞与细胞间的直接接触。这些膜包囊颗粒被称为细胞外囊泡(EVSs),肿瘤细胞比正常细胞可分泌更多的EVSs,这些EVSs通过依赖于内体分选复合物蛋白(ESCRT)和不依赖于ESCRT的途径将蛋白质、DNA、RNA等“内容物”分选入体内。这些“内容物”促进肿瘤细胞与基质细胞之间的信息的转递,从而支持肿瘤血管生成,侵袭转移、耐药及使得肿瘤细胞获得恶性表征。Tumor growth, invasion and metastasis depend on the "cross-talk" between tumor cells and stromal cells in their microenvironment, which mainly involves the secretion of soluble factors of these two kinds of cells, the release of membrane-tomont particles and the direct contact between cells. These vesicles are known as extracellular vesicles (EVSs), and tumor cells secrete more EVSs than normal cells, which separate proteins, DNA, RNA, and other "contents" into the body through both escrt-dependent and escrt-independent pathways. These "contents" facilitate the transmission of information between tumor cells and stromal cells, thus supporting tumor angiogenesis, invasion and metastasis, drug resistance, and malignant characterization of tumor cells.

关 键 词：细胞外囊泡 信号分选 肿瘤微环境 肿瘤-基质细胞 

分 类 号：R730.2[医药卫生—肿瘤]