二噁英暴露和子宫内膜异位症相关性  

Relationship between dioxins exposure and endometriosis

作　　者：刘娟[1] 陈灿明[1] 徐杨 张玮[1] 张磊[1] LIU Juan;CHEN Canming;XU Yang;ZHANG Wei;ZHANG Lei(Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Yangzhou, Jiangsu Province, Yangzhou 225000, China)

机构地区：[1]扬州市妇幼保健院妇产科

出　　处：《中国医药导报》2019年第18期85-89,共5页China Medical Herald

基　　金：江苏省卫生计生委科研课题(Z201524);江苏省扬州市重点研发计划-社会发展项目(YZ2015053)

摘　　要：目的探讨二噁英暴露与子宫内膜异位症的相关性,为子宫内膜异位症临床防治提供理论依据。方法选择2016年12月~2019年1月因盆腔包块于江苏省扬州市妇幼保健院住院手术治疗的患者50例,其中术后病理确诊为子宫内膜异位症者25例为病例组,非子宫内膜异位症者25例为对照组。采用自制问卷调查的方式,分析二噁英暴露与子宫内膜异位症相关性;收集两组血液,使用同位素内标稀释-索式萃取一段法层析柱净化-高分辨气质联用分析方法检测两组患者血液中二噁英浓度并进行比较分析。结果病例组经常烧饭、烧菜者占比高于对照组,经常食用鸭蛋和鹌鹑蛋者占比低于对照组,差异有统计学意义(P <0.05)。病例组血液中二噁英化合物多氯代二苯并呋喃、2,3,7,8-四氯代二苯并呋喃(2,3,7,8-T4CDF)、1,2,3,7,8-五氯代二苯并呋喃(1,2,3,7,8-P5CDF)和2,3,4,7,8-五氯代二苯并呋喃(2,3,4,7,8-P5CDF)的浓度和毒性当量高于对照组,差异有统计学意义(P <0.05)。结论二噁英暴露与子宫内膜异位症二者存在相关性,经常烧饭、烧菜可能是子宫内膜异位症患者暴露二噁英的环境危险因素之一。Objective To investigate the relationship between dioxins exposure and endometriosis, and to provide theoretical basis for the prevention and treatment of disease. Methods From December 2016 to January 2019, 50 patients with pelvic pack block in Maternal and Child Health Hospital of Yangzhou were selected, and 25 patients with endometriosis confirmed by pathology after surgery were set as the case group, 25 patients without endometriosis were set as control group. The correlation between dioxins exposure and endometriosis was analyzed by means of homemade questionnaire survey, and blood specimens from patients were collected to detect dioxin levels of blood by Soxhlet extraction chromatography column purification-isotope dilution HRGC-HRMS, and those results were compared between the two groups. Results The proportion of people who cook regularly in case group were significantly higher than that in control group, the proportion of people who often eat duck and quail eggs in case group were lower than that in control group, the differences were statistically significant(P < 0.05). The contents and the toxic equivalence of dioxins such as Polychlorinated Dibenzofura, 2,3,7,8-Tetrachlorodibenzofuran(2,3,7,8-T4 CDF), 1,2,3,7,8-Pentachlorodibenzofuran(1,2,3,7,8-P5 CDF) and 2,3,4,7,8-Pentachlorodibenzofuran(2,3,4,7,8-P5 CDF) in the blood of case group were significantly higher than those of control group, the differences were statistically significant(P < 0.05). Conclusion The association exits between dioxins exposure and endometriosis, and cooking regularly might be a risk factor for exposure dioxins for endometriosis.

关 键 词：子宫内膜异位症 二噁英 环境危险因素 病例对照研究 

分 类 号：R711.71[医药卫生—妇产科学]