不明原因反复自然流产患者外周血抗凝血因子、凝血相关因子水平及临床意义  

The levels and clinical significance of anticoagulant factor, coagulation- related factor in peripheral blood of patients with unexplained recurrent spontaneous abortion

作　　者：陈婵 CHEN Chan(Department of Obstetrics and Gynecology,the Fourth Peopled Hospital of Haihou,Haihou,Hainan 570000,China)

机构地区：[1]海口市第四人民医院妇产科

出　　处：《中国卫生检验杂志》2019年第13期1591-1594,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨不明原因反复自然流产患者外周血抗凝血因子、凝血相关因子水平及临床意义。方法选取2014年2月-2017年5月就诊治疗的80例反复自然流产患者为研究对象,并选取80例门诊行无痛人流的妊娠5周~10周的早孕患者、78例同期门诊行宫内节育器放置术1次~2次正常生育史非孕期妇女,比较3组患者血清中F1+2、TAT、AT-Ⅲ、PAI-1、APTT、PT、TT、FIB水平差异。结果反复自然流产组中的F1+2、TAT、PAI-1水平均高于非正常妊娠组和正常未孕组,反复自然流产组中的AT-Ⅲ水平低于非正常妊娠组和正常未孕组,差异均有统计学意义(P<0.05)。APTT、PT、TT指标水平在正常未孕组、非正常妊娠组、反复流产组之间呈逐渐降低的趋势(P<0.05),而FIB指标水平呈逐渐升高的趋势(P<0.05)。结论对患者外周血凝血、抗凝血相关因子进行检测并及时进行抗凝治疗,可降低不明原因反复自然流产患者的流产率。Objective To investigate the levels and clinical significance of anticoagulant factor,coagulation related factors in patients with recurrent spontaneous abortion.Methods Eighty patients with recurrent spontaneous abortion who were treated from February 2014 to May 2017 were selected as subjects.Eighty patients with early pregnancy who had painless abortions from 5 to 10 weeks of pregnancy and 78 patients with intrauterine birth control during the same period were selected.The patients were placed in the normal non-pregnancy period 1 to 2 times.The serum levels of F1+2,TAT,AT-Ⅲ,PAI-1,APTT,PT,TT and FIB were compared among the three groups.Results The levels of F1+2,TAT and PAI-1 in the recurrent spontaneous abortion group were higher than those in the non-normal pregnancy group and the normal non-pregnant group.The level of AT-Ⅲ in the recurrent spontaneous abortion group was lower than that in the non-normal pregnancy group and the normal non-pregnant group.The above differences were statistically significant(P<0.05).The levels of APTT,PT and TT showed a gradual decrease in the normal non-pregnant group,abnormal pregnancy group and repeated abortion group(P<0.05),while the FIB index level gradually increased(P<0.05).Conclusion The detection of peripheral blood coagulation and anticoagulant related factors in patients and timely anticoagulant therapy can reduce the abortion rate of patients with unexplained recurrent spontaneous abortion.

关 键 词：不明原因反复自然流产 外周血抗凝血因子 凝血相关因子水平 临床意义 

分 类 号：R714.21[医药卫生—妇产科学]