无瓣海桑果实提取物对D-半乳糖致衰老小鼠抗氧化能力的影响  

Effect of the Extracts of Sonneratiaapetala Fruit on Antioxidative Ability in Aging Mice Induced by D-galactose

作　　者：李家怡 易湘茜 杜正彩[1] 高程海 郝二伟 邓家刚 Li Jiayi;Yi Xiangxi;Du Zhengcai;Gao Chenghai;Hao Erwei;Deng Jiagang(School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530020, China;School of Pharmacy, Jinan University, Guangzhou 510632, China;Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China)

机构地区：[1]广西中医药大学药学院,南宁530020 [2]暨南大学药学院,广州510632 [3]广西壮族自治区药用植物研究所,南宁530023

出　　处：《世界科学技术-中医药现代化》2019年第4期647-651,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广西科学技术厅中药药效研究重点实验室建设项目(17-259-20):广西中药药效研究重点实验室,负责人:邓家刚;中国博士后管理委员会中国博士后科学基金面上资助项目(2016M602920XB):红树白骨壤果实中苯乙醇苷类化合物调控VD信号通路研究,负责人:易湘茜;广西壮族自治区人力资源与社会保障厅博士后专项资助项目:易湘茜博士后常规性资助,负责人:易湘茜

摘　　要：目的:研究无瓣海桑(Sonneratiaapetala)果实提取物对D-半乳糖致衰老小鼠抗氧化能力的影响。方法:选用D-半乳糖(D-gal)诱导建立衰老小鼠模型,并分别灌胃无瓣海桑果实醇提物、乙酸乙酯提取物和正丁醇提取物,观察无瓣海桑果实各提取物对衰老小鼠血清、心脏和肝脏组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)的影响。结果:与模型组相比,无瓣海桑果实提取物可以有效提高衰老小鼠体内SOD、GSH-Px酶活力,降低MDA含量(P <0.05)。结论:无瓣海桑果实提取物能有效提高D-半乳糖致衰老小鼠体内抗氧化能力从而达到延缓衰老的作用。To study the effect of extracts of Sonneratiaapetala fruit on the antioxidant capacity of aging mice induced by D-galactose. D-galactose (D-gal) was selected to establish a mouse model of aging. The aged mice were fed with extracts of Sonneratiaapetala fruit, alcohol extracts, and ethyl acetate extracts respectively. The effects of extracts on superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and malondialdehyde(MDA) in serum, heart and liver of aging mice were observed. The experimental results show that, compared with the model group, the extract of Sonneratiaapetala fruit can effectively increase the activity of SOD and GSH-Px enzymes and reduce the content of MDA in aging mice(P< 0.05). The results showed that the extract of Sonneratiaapetala fruit extract can effectively improve the anti- oxidation ability of aging mice induced by D-galactose, so as to achieve the effect of delaying aging.

关 键 词：无瓣海桑果实 抗衰老 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R285[医药卫生—中药学]