Brugada综合征的诊断及治疗进展  

Progress of diagnosis and treatment in brugada syndrome

作　　者：张春兰 宋旭东[1] 刘磊[1] 阙冬冬[1] 杨平珍[1] ZHANG Chun-lan;SONG Xu-dong;LIU Lei;QUE Dong-dong;YANG Ping-zhen(Department of Cardiovascular Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China)

机构地区：[1]南方医科大学珠江医院心血管内科

出　　处：《中国分子心脏病学杂志》2019年第3期2939-2943,共5页Molecular Cardiology of China

基　　金：南方医科大学临床研究启动计划项目(LC2016ZD022)

摘　　要：Brugada综合征(Brugada Syndrome,BrS)是一种致心律失常的遗传性离子通道病,ECG特征是V1-V3 ST段抬高及J波上移。有极高的室速(Ventricular tachycardia,VT)/室颤(ventricular fibrillation,VF)及心脏骤停(Cardiac arrest)的风险。BrS的首选治疗是植入埋藏式心脏电除颤器(Implantable cardioverter defibrillator,ICD),联合药物治疗及心外膜消融可以减少恶性心律失常发生。本综述简要概括了BrS的临床诊断、分子学说、致病基因及治疗进展。Brugada Syndrome (BrS) is an arrhythmogenic hereditary ion channel disease characterized by ST-segment elevation and J-wave up-regulation of the precordial lead electrocardiogram (V1-V3). There is a high risk of ventricular tachycardia (VT)/ventricular fibrillation (VF) and cardiac arrest. The primary treatment for BrS is the implantation of an implantable cardioverter defibrillator (ICD). Combination therapy and epicardial radiofrequency ablation can reduce the occurrence of electrical storms. This review provides a brief overview of the clinical diagnosis, molecular theory, genetics basis, and treatment of BrS.

关 键 词：BRUGADA综合征 室速 室颤 电风暴 射频消融 

分 类 号：R541.7[医药卫生—心血管疾病]