中国家庭护理对阿尔茨海默病患者健康状况影响的meta分析  

Effect of family nursing on health status in patients with Alzheimer’s disease in China:a meta-analysis

作　　者：叶佳欣 江丽丽 高银燕[1] 何文博 陈雅静 YE Jia-xin;JIANG Li-li;GAO Yin-yan;HE Wen-bo;CHEN Ya-jing.(Institute of Social Medicine and Health Management,College of Public Health of Lanzhou University, Lanzhou 730000, China)

机构地区：[1]兰州大学公共卫生学院社会医学与卫生事业管理学研究所

出　　处：《华南预防医学》2019年第3期227-232,共6页South China Journal of Preventive Medicine

基　　金：甘肃省自然科学基金项目(1506RJZA229)

摘　　要：目的分析中国家庭护理对阿尔茨海默病患者健康状况的影响。方法检索Cochrane Library、EMbase、Pubmed、Web of Science、维普、万方、中国知网、CBM从建库至2018年5月中国家庭护理对阿尔茨海默病患者健康影响的随机对照试验(RCTs)。由2名研究员按纳入和排除标准独立筛选文献,并手动检索纳入研究的参考文献,按Cochrane Handbook 5.1.0的质量评价标准对纳入的研究进行质量评价,用Revman 5.3对患者的精神智力状态、健康状况、抑郁情绪和日常生活能力进行meta分析。结果共纳入13篇RCTs,共919例阿尔茨海默病患者,其中干预组459例,对照组460例,纳入研究的质量均为B等级。Meta分析结果显示,干预组的精神智力状况(MD=2.53,95%CI:1.75~3.32,P<0.01)、抑郁情绪(SMD=-1.05,95%CI:-1.76^-0.34,P<0.01)、健康状况(MD=143.73,95%CI:107.45~180.00,P<0.01)、日常生活能力(SMD=0.53,95%CI:0.24~0.83,P<0.01)、自理能力(SMD=0.77,95%CI:0.55~0.98,P<0.01)均优于对照组。结论家庭护理可以有效改善阿尔茨海默病患者的精神智力状态、健康状况、抑郁情绪和日常生活能力。Objective To evaluate the effect of family nursing on patients with Alzheimer’s disease(AD)in China. Methods Databases,such as Cochrane Library,EMbase,Pubmed,Web of Science,VIP,Wanfang,CNKI,CBM,were searched for the randomized controlled trials(RCTs)that assessed the effectiveness of family nursing for the elderly with AD from inception to May 2018. Literatures were selected according to the inclusion and exclusion criteria and corresponding references were searched manually by two investigators independently. The quality of the included studies was evaluated according to the quality evaluation criteria of Cochrane Handbook 5.1.0. The Meta-analysis of mental status,health status,depression and the activities of daily living was performed by using Revman 5.3 software. Results Thirteen RCTs involving 919 AD patients,including 459 patients in the intervention group and 460 patients in the control group,were included. The quality of the included studies was Grade B. Meta-analysis indicated that the mental status(MD=2.53,95% CI:1.75-3.32),P<0.01),depression status(SMD=-1.05. 95%CI:-1.76--0.34),P<0.01),health status(MD = 143.73,95% CI:107.45-180.00,P <0.01),ability of daily life(SMD = 0.53,95% CI:0.24-0.83,P<0.01),and self-care(SMD=0.77,95%CI:0.55-0.98,P<0.01)in the intervention group were better than those in the control group. Conclusion Family nursing can improve mental status,health status,depression and the activities of daily living in AD patients.

关 键 词：家庭护理 阿尔茨海默病 META分析 

分 类 号：R494[医药卫生—康复医学]