伊可新滴剂联合普米克令舒治疗毛细支气管炎患儿的疗效及其对血清SIL-2R、CysLTs、Eotaxin的影响  

Therapeutic efficacy of icosin drops combined with pulmicort respules in the treatment of children with bronchiolitis and its effects on serum SIL-2R,CysLTs and Eotaxin levels

作　　者：程小宁[1] 薛静[2] 马选鹏[3] CHENG Xiao-ning;XUE Jing;MA Xuan-pen(Department of Pediatrics,the Second Affiliated Hospital,Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;Department of Clinical Laboratory,the Second Affiliated Hospital,Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China;Department of Interventional Radiology,the Second Affiliated Hospital,Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院儿科,陕西咸阳712000 [2]陕西中医药大学第二附属医院检验科,陕西咸阳712000 [3]陕西中医药大学第二附属医院介入放射科,陕西咸阳712000

出　　处：《实用药物与临床》2019年第7期722-725,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨伊可新滴剂联合普米克令舒治疗毛细支气管炎患儿的疗效及其对血清可溶性白细胞介素-2受体(SIL-2R)、半胱氨酰白三烯(CysLTs)、嗜酸性粒细胞趋化蛋白(Eotaxin)的影响.方法选取我院2016年1月至2018年4月所收治的90例毛细支气管炎患儿作为研究对象,按照随机数表法分为观察组46例,对照组44例.在常规治疗基础上,对照组给予普米克令舒治疗,观察组在对照组的基础上,给予伊可新滴剂治疗,均连续治疗7d.比较两组血清SIL-2R、CysLTs、Eotaxin的变化,临床疗效,临床症状改善时间及不良反应.结果治疗后,观察组总有效率高于对照组(93.48%vs.77.27%,P<0.05),血清SIL-2R、CysLTs、Eotaxin低于对照组[(151.23±10.08)pg/mlvs.(165.81±12.42)pg/ml,(24.59±3.07)ng/mlvs.(32.37±4.33)ng/ml,(14.94±2.56)ng/Lvs.(22.15±2.88)ng/L,P<0.05],咳嗽、喘憋、肺部湿啰音、哮鸣音、气促改善时间较对照组缩短[(3.16±0.65)dvs.(4.17±0.74)d,(3.49±0.47)dvs.(4.26±0.58)d,(3.94±0.55)dvs.(4.73±0.60)d,(3.28±0.37)dvs.(3.95±0.48)d,(2.98±0.4)dvs.(3.76±0.50)d,P<0.05].治疗期间两组患儿无明显不良反应发生.结论伊可新滴剂联合普米克令舒在毛细支气管炎患儿的治疗中效果显著,可有效降低血清SIL-2R、CysLTs、Eotaxin的表达,促进疾病恢复,安全性高.Objective To study the curative efficacy of icosin drops combined with pulmicort respules in the treatment of children with bronchiolitis and its effect on serum interleukin-2 receptor ( SIL-2R), cysteinyl leukotriene ( CysLTs) and eosinophilic chemoattractant protein ( Eotaxin) levels. Methods Totally 90 children with bronchiolitis who received treatment from January 2016 to April 2018 in our hospital were selected as research objects,and they were divided into observation group ( n = 46) and control group ( n = 44),according to the random number table. Patients in control group was given pulmicort respules on the basis of routine treatment,while those in observation group were given icosin drops on the basis of treatment for control group. All the patients were treated continuously for 7 days. The clinical efficacy,changes of serum SIL-2R, CysLTs and Eotaxin, improvement time of clinical symptoms and adverse reactions were compared between the two groups. Results After treatment,the total effective rate of observation group was higher than that of control group ( 93. 48% vs. 77. 27%, P < 0. 05);the serum levels of SIL-2R, CysLTs and Eotaxin in observation group were lower than those in control group [( 151. 23 ± 10. 08) pg /ml vs.( 165. 81 ± 12. 42) pg /ml,( 24. 59 ± 3. 07) ng /ml vs.( 32. 37 ± 4. 33) ng /ml,( 14. 94 ± 2. 56) ng /L vs.( 22. 15 ± 2. 88) ng /L, P < 0. 05];the improvement time of cough,asthmatic suffocation,lung rales, wheezing and shortness of breath in observation group were significantly shorter than those in control group[( 3. 16 ± 0. 65) d vs.( 4. 17 ± 0. 74) d,( 3. 49 ± 0. 47) d vs.( 4. 26 ± 0. 58) d,( 3. 94 ± 0. 55) d vs.( 4. 73 ± 0. 60) d,( 3. 28 ± 0. 37) d vs.( 3. 95 ± 0. 48) d,( 2. 98 ± 0. 4) d vs.( 3. 76 ± 0. 50) d,P < 0. 05]. No obvious adverse reaction occurred in the two groups during treatment. Conclusion Icosin drops combined with pulmicort respules has good efficacy for children with bronchiolitis,which can effectively reduce the expression of SIL-2R,CysLTs and Eot

关 键 词：毛细支气管炎 普米克令舒 伊可新滴剂 白细胞介素-2受体 半胱氨酰白三烯 嗜酸性粒细胞趋化蛋白 

分 类 号：R725.6[医药卫生—儿科]