复方甘草酸苷注射液的临床应用及分析  

Clinical Application of Compound Glycyrrhizin Injection

作　　者：魏洁 颜元良 曾双双[1] 徐志杰[2] 刘万里[1] 龚志成[1] WEI Jie;YAN Yuanliang;ZENG Shuangshuang;XU Zhijie;LIU Wanli;GONG Zhicheng(Department of Pharmacy,Xiangya Hospital of Central South University,National Clinical Research Center for Geriatric Disorders ,Changsha,Hunan,China 410008;Department of Pathology,Xiangya Hospital of Central South University,Changsha,Hunan,China 410008)

机构地区：[1]中南大学湘雅医院药学部·国家老年疾病临床医学研究中心<湘雅>,湖南长沙410008 [2]中南大学湘雅医院病理科,湖南长沙410008

出　　处：《中国药业》2019年第15期79-81,共3页China Pharmaceuticals

基　　金：中南大学临床大数据系统建设项目[中南大学临床大数据系统建设项目46号];中南大学湘雅医院医院管理研究基金[2016GL21]

摘　　要：目的分析复方甘草酸苷注射液的使用特点及规律,促进临床合理用药。方法调取电子病历系统住院部皮肤科2016年至2018年使用复方甘草酸苷注射液患者的诊断、用量、溶剂和合并用药等信息。结果691例患者中,男425例,女266例;主要用于治疗湿疹(25.90%)、银屑病(22.58%)和药物性皮炎(11.58%);均采用静脉滴注,86.46%的患者日使用剂量为40~60mL,13.07%的患者为80mL,0.46%的患者为20mL;溶剂多采用5%葡萄糖注射液(81.23%),其次为木糖醇注射液(18.13%)、0.9%氯化钠注射液(0.43%)、10%葡萄糖注射液(0.16%);5 369例次(95.64%)与维生素C注射液同瓶静脉滴注,6例患者合并使用氨溴索,10例患者合并使用呋塞米;可见精神欠佳、乏力等症状,疑与药物相互作用相关。结论复方甘草酸苷注射液临床使用日剂量普遍大于药品说明书皮肤病推荐剂量,但未超过慢性肝炎推荐剂量。该注射液药品说明书对溶剂未作明确要求,临床使用多种不同溶剂,常与维生素C同瓶注射。存在超适应证用药及配伍禁忌现象,有待干预,以促进临床合理用药。Objective To analyze the characteristics and rules of clinical use of Compound Glycyrrhizin Injection to promote rational drug use in the clinic.Methods By electronic medical record system,inpatients who used Compound Glycyrrhizin Injection were collected from 2016 to 2018 in the Department of Dermatology to analyze the diagnosis,dosage,solvent and concomitant medication.Results Among 691 patients,425 were males and 266 were females.Compound Glycyrrhizin Injection was mainly used for the treatment of eczema(25.90%),psoriasis(22.58%)and drug-induced dermatitis(11.58%).All patients used intravenous drip with the daily dose of 40-60 m L(86.46%),80 m L(13.07%)and 20 m L(0.46%).5%Glucose Injection(81.23%)was the used most solvent,followed by Xylitol Injection(18.13%),0.9%Sodium Chloride Injection(0.43%),and 10%Glucose Injection(0.16%).Totally 5 369 cases(95.64%)were intravenously dripped with Vitamin C Injection in the same bottle,6 cases were combined with ambroxol,10 cases were combined with furosemide,and symptoms such as poor spirit and fatigue were found,which were suspected to be related to drug interactions.Conclusion The daily dose of Compound Glycyrrhizin Injection in clinical use is generally higher than the recommended dose of skin disease,but not chronic hepatitis in drug instructions.The drug instructions for this injection don’t explicitly requirements for the solvent,while it is aften injected with vitamin C in the same bottle,and also with a variety of different solvents in the clinic.Also,inappropriate use such as medication without indication and incompatibility are found during clinical treatment,which need to be intervened to promote the rational use of drugs in the clinic.

关 键 词：皮肤科 复方甘草酸苷注射液 剂量 溶剂 配伍禁忌 合理用药 

分 类 号：R969.3[医药卫生—药理学] R986[医药卫生—药学]