环状RNA在糖尿病中的研究进展  

Research Progress of Circular RNA in Diabetes Mellitus

作　　者：刘婷婷 张海东 王静 谢俊豪 金百翰 黄勤 LIU Tingting;ZHANG Haidong;WANG Jing;XIE Junhao;JIN Baihan;HUANG Qin(Department of Endocrinology,Changhai Hospital of Naval Military Medical University,Shanghai 200433,China;Health Team,PLA 72506,Zhumadian 463200,China)

机构地区：[1]海军军医大学长海医院内分泌科,上海200433 [2]解放军72506部队卫生队,河南驻马店463200

出　　处：《医学综述》2019年第13期2665-2669,共5页Medical Recapitulate

基　　金：国家自然科学基金(81471038,81272665);国家卫生和计划生育委员会公益性行业科研基金资助项目(201502011)

摘　　要：环状RNA(circRNA)是一种由外显子和(或)内含子共同组成的非编码RNA,其结构呈首尾相接的封闭环状,具有时空特异性、高度的进化保守性及稳定性、广泛性等生物学特征。circRNA具有海绵样吸附、调控基因的转录、与RNA结合蛋白相互作用以及参与蛋白质的翻译等多种生物学功能,可调节胰岛β细胞的功能参与糖尿病的发生、发展,并与糖尿病大血管病变、微血管病变和周围神经病变等并发症均有关。此外,circRNA亦可能作为糖尿病诊断和预测的潜在生物学标志物。Circular RNA(circRNA) is a non-coding RNAs composed of exons and/or introns.Its structure is closed-loop with end-to-end closure.It is characterized by space-time specificity,high evolutionary conservation,stability and universality.CircRNA has a variety of biological functions,such as spongy adsorption,regulation of gene transcription,interaction with RNA binding protein and protein translation.CircRNA can regulate the function of β cells in the development and progression of diabetes and is associated with diabetic complications such as macrovascular disease,microvascular disease and peripheral neuropathy.In addition,circRNA may also serve as a potential biomarker for the diagnosis and prediction of diabetes mellitus.

关 键 词：糖尿病 环状RNA 胰岛Β细胞 

分 类 号：R58[医药卫生—内分泌]