大剂量免疫球蛋白对狼疮肾治疗作用研究  

Therapeutic Effect of High-Dose Immunoglobulin on Lupus Kidney

作　　者：梁师钢 LIANG Shi-gang(Department of Internal Medicine,Third People's Hospital of Yangxin County,Huangshi,Hubei Province,435200 China)

机构地区：[1]湖北省黄石市阳新县第三人民医院内一科

出　　处：《中外医疗》2019年第16期4-6,共3页China & Foreign Medical Treatment

摘　　要：目的探讨大剂量免疫球蛋白对狼疮肾治疗效果,分析大剂量免疫球蛋白的治疗作用。方法方便选取该院于2016年10月—2018年10月收治的40例狼疮肾炎患者作为研究对象,采用硬币法分为对照组与观察组,各组20例。对照组采用激素联合环磷酰胺治疗,观察组在对照组基础上采用大剂量免疫球蛋白治疗。治疗2个月观察与比较两组患者的系统性红斑狼疮病情活动度、尿蛋白、血浆白蛋白变化情况。结果观察组患者治疗后系统性红斑狼疮病情活动度评分结果为(1.34±1.17)分,低于对照组,差异有统计学意义(t=6.017,P<0.05)。观察组尿蛋白检测结果为(1.94±1.23)g/L,低于对照组,差异有统计学意义(t=5.635,P<0.05)。观察组治疗后血浆白蛋白检测结果为(30.14±10.15)g/L,高于对照组,差异有统计学意义(t=6.318,P<0.05)。结论大剂量免疫球蛋白联合糖皮质激素、环磷酰胺治疗狼疮肾炎可以改善患者的尿蛋白、血浆白蛋白水平,具有良好的临床治疗效果,值得应用。Objective To investigate the therapeutic effect of high-dose immunoglobulin on lupus kidney and analyze the therapeutic effect of high-dose immunoglobulin.Methods Forty patients with lupus nephritis admitted to our hospital from October 2016 to October 2018 were convenient enrolled in the study.According to coin method,they were divided into the control group and the observation group,with 20 cases in each group.The control group was treated with glucocorticoid combined with cyclophosphamide,while the observation group was treated with high-dose immunoglobulin on the basis of the control group.Two months after treatment,the activity of systemic lupus erythematosus,urine protein and plasma albumin were observed and compared between the two groups.Results The scores of systemic lupus erythematosus activity in the observation group were(1.34±1.17)points,which was lower than the control group(t=6.017,P<0.05),with statistical significance.The urine protein test results of the observation group were(1.94±1.23)g/L,which was lower than the control group(t=5.635,P<0.05),with statistical significance.The plasma albumin test results of the observation group were(30.14±10.15)g/L,which was higher than that of the control group(t=6.318,P<0.05),with statistical significance.Conclusion High-dose immunoglobulin combined with glucocorticoid and cyclophosphamide can improve the urinary protein and plasma albumin levels in patients with lupus nephritis.It has good clinical therapeutic effect and is worthy of application.

关 键 词：狼疮肾炎 免疫球蛋白 环磷酰胺 糖皮质激素 血浆白蛋白 效果 

分 类 号：R4[医药卫生—临床医学]