人参皂苷活性单体-20(R)-人参皂苷Rg3药理作用及其机制的研究进展  

Advances in the research of pharmacological effects and its mechanisms of 20(R)-ginsenoside Rg3

作　　者：陈德云 沈志强 何波 CHEN De-yun;SHEN Zhi-qiang;HE Bo(School of Pharmaceutical Science & Yunnan Key Laboratory ofPharmacology for Natural Products,Kunming Medical University, 650500 ,China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室

出　　处：《天然产物研究与开发》2019年第7期1285-1290,共6页Natural Product Research and Development

基　　金：国家自然科学基金(81441129,81660613,81860665);云南省应用基础研究-昆医联合专项(2013FZ268);昆明医科大学“百名中青年学术和技术骨干”培养计划(60117190442)

摘　　要：20(R)-人参皂苷Rg3是人参皂苷的主要活性单体之一,主要用于抗肿瘤治疗。近年来,20(R)-人参皂苷Rg3的药理作用不断取得进展,其中保护心脑血管、增强免疫功能、抗增生性瘢痕、抗疲劳的药理作用尤为值得关注。本文整理近年来国内外与20(R)-人参皂苷Rg3相关文献,论述其主要药理作用及其作用机制,为进一步开发20(R)-人参皂苷Rg3提供了科学依据。20(R)-ginsenoside Rg3 was one of the major active components of ginseng saponins and was mainly used in anti-tumor therapy.In recent years,the pharmacological effects of 20(R)-ginsenoside Rg3 had made continuous progress.It was important to pay attention to the pharmacological effects of 20(R)-ginsenoside Rg3,especially the protective effects on cardio-cerebrovascular diseases,immune function enhancement,anti-hypertrophic scar and anti-fatigue activities.In this article,we summarized the relevant literature on 20(R)-ginsenoside Rg3 at home and abroad,and discussed its pharmacological effects and molecular mechanisms,which provided a scientific basis for the further research.

关 键 词：20(R)-人参皂苷Rg3 皂苷单体 药理作用 作用机制 

分 类 号：R961[医药卫生—药理学]