波动性高糖对糖尿病视网膜病变的作用研究进展  

Research progress on the effect of high glucose fluctuations on the pathogenesis of diabetic retinopathy

作　　者：董天慧 孙建梅 姚舜[1] 邹斌倩 蒲泽南 何雷[1] DONG Tianhui;SUN Jianmei;YAO Shun;ZOU Binqian;PU Zenan;HE Lei(Endocrinology Department,Zhujiang Hospital of Southern Medical University,Guangzhou,Guangdong 510280,China;School of Laboratory Medicine and Biotechnology,Southern Medical University,Guangzhou,Guangdong 510280,China)

机构地区：[1]南方医科大学珠江医院内分泌科,广东广州510280 [2]南方医科大学检验与生物技术学院,广东广州510280

出　　处：《安徽医药》2019年第8期1485-1488,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病微血管严重并发症之一,其发生发展不仅与长期的高血糖水平有关,而且与血糖波动幅度呈现明显正相关。波动性高糖通过启动细胞自噬和细胞凋亡,激活氧化应激,损伤视网膜组织DNA,促进血管内皮生长因子(vascular endothelial growth factor,VEGF)的释放等多种途径参与DR的发生进展。Diabetic retinopathy(DR) is one of the most serious diabetic microvascular complications.Its development and progression is not only related to long-term hyperglycemia,but also positively correlated with blood glucose fluctuations.High glucose fluctuations contribute to diabetic retinopathy through the following ways:inducing autophagy and apoptosis,activating oxidative stress,damaging DNA in retinal tissue cells,promoting the release of vascular endothelial growth factor(VEGF).This article is a brief review of contribution of high glucose fluctuations to DR.

关 键 词：糖尿病视网膜病变 血管内皮生长因子类 细胞凋亡 自噬 氧化性应激 DNA损伤 波动性高糖 综述 

分 类 号：R587.2[医药卫生—内分泌]