山羊正常腰椎椎体、软骨终板和髓核弥散特性的DCE-MRI研究  

Diffusion characteristics of lumbar vertebrae,cartilage endplate and nucleus pulposus in normal goats by dynamic contrast enhanced MRI

作　　者：尹思 杜恒 赵为公 麻少辉[2] 张明[2] 管民[3] 刘淼 YIN Si;DU Heng;ZHAO Weigong;MA Shaohui;ZHANG Ming;GUAN Min;LIU Miao(Department of Orthopaedic Surgery,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710065,China;Department of Medical Imaging,First Affiliated Hospital of Xi’an Jiaotong University;Department of Medical Imaging,Henan Provincial People’s Hospital)

机构地区：[1]西安交通大学第一附属医院骨科,西安710065 [2]西安交通大学第一附属医院影像科 [3]河南省人民医院影像科

出　　处：《山西医科大学学报》2019年第7期975-980,共6页Journal of Shanxi Medical University

基　　金：陕西省自然科学基础研究计划项目(2019JM-558);中央高校基本科研业务费专项基金资肋(xjh012019062)

摘　　要：目的利用不同对比剂通过动态增强MRI(DCE-MRI)研究山羊正常腰椎椎体、软骨终板和髓核弥散的途径及特性。方法选取8只成年雌性山羊,麻醉后静脉推注钆贝葡胺(Gd-BOPTA)行DCE-MRI扫描,剂量均为0.3 mmol/kg,观察山羊腰椎椎体、软骨终板和髓核中的感兴趣区域(ROI)的信号强度变化。参加上述实验的山羊饲养1周后,采用同样方法和剂量进行钆双胺(Gd-DTPA-B)DCE-MRI扫描。分别测量山羊腰椎椎体、软骨终板和髓核增强前及增强后0 min,5 min,10 min,30 min,1 h,1.5 h,2 h,2.5 h的ROI信号强度值,绘制时间-增强率曲线并进行分析对比。结果静注Gd-BOPTA 0 min后,椎体信号强度上升至5 min时达到高峰(增强率216.1%±23.3%),然后缓慢下降,于1.5-2.5 h时再次缓慢上升;软骨终板区时间-增强率曲线与椎体大致相同,至5 min时上升至最高峰(增强率168.7%±39.4%),而后下降趋势较为平缓;髓核时间-增强率曲线呈缓慢上升趋势,至2 h时达到最高峰(增强率102.4%±21.4%),其后迅速下降。静注Gd-DTPA-B后,椎体信号强度从0 min开始迅速上升,上升幅度较Gd-BOPTA低,5 min时达到高峰(增强率119.1%±6.81%),其后缓慢下降,2.5 h时趋于平缓;软骨终板区信号强度从0 min开始上升,10 min时上升至最高峰(增强率81.6%±16.8%),其后下降趋势较为平缓;髓核区信号强度在5 min内显示为负值,之后缓慢上升,2.5 h时达到最高峰(增强率88.5%±7.56%)。两组对比剂在山羊椎体、软骨终板中增强率的最高峰值之间差异有统计学意义(P<0.01),而在山羊腰椎髓核中增强率的最高峰值之间差异无统计学意义(P=0.11)。结论利用DCE-MRI技术可以动态模拟山羊腰椎椎体、软骨终板和髓核弥散的途径,而且溶质的剂量、电磁性和分子量都是影响终板弥散过程的重要因素。Objective To study the diffusion pathway and characteristics of lumbar vertebrae,cartilage endplate and nucleus pulposus in normal goats using dynamic contrast enhanced MRI(DCE-MRI)with two different contrast agents.Methods Eight adult female goats were selected as experiment samples.After anesthesia,DCE-MRI examinations were performed in the goats with intravenous injection of gadobenate dimeglumine(Gd-BOPTA)and gadodiamide(Gd-DTPA-B)at a dosage of 0.3 mmol/kg,respectively.The signal intensities of regions of interest(ROI)in the vertebrae,cartilage endplate and nucleus pulposus were measured before enhancement,and 0 min,5 min,10 min,30 min,1 h,1.5 h,2 h,and 2.5 h after enhancement,respectively,and the time-signal intensity curves were drawn and analyzed.Results After intravenous administration of Gd-BOPTA,the signal intensity in the vertebrae reached a peak(216.1%±23.3%)at 5 min after enhancement and then decreased gradually,and started rising again 1.5-2.5 h after enhancement.The time-signal intensity curve in the cartilage endplate region was similar with that in the vertebrae,with a peak of signal intensity at 168.7%±39.4%.The signal intensity in the nucleus pulposus showed a slow upward trend,and reached a peak(102.4%±21.4%)at 2 h,and decreased rapidly afterwards.After intravenous administration of Gd-DTPA-B,the signal intensity in the vertebrae reached a peak(119.1%±6.81%)at 5 min,decreased gradually and began to flatten at 2.5 h.The signal intensity in the cartilage endplate region reached a peak(81.6%±16.8%)at 10 min,and decreased gradually afterwards.The signal intensity in the nucleus pulposus was negative within 5 min,and increased slowly to a peak(88.5%±7.56%)at 2.5 h.There was significant difference in the maximal signal intensities in the vertebrae and cartilage endplate between two contrast agents(P<0.01),however,there was no signi-ficant difference in the maximal signal intensities in the nucleus pulposus(P=0.11).Conclusion The diffusion pathway of lumbar vertebrae,cartilage endplate and nuc

关 键 词：动态增强MRI 软骨终板 弥散 对比剂 钆贝葡胺 钆双胺 

分 类 号：R445.2[医药卫生—影像医学与核医学]