2013-2017年北京市门头沟区感染性腹泻病原菌监测结果分析  

Etiologic surveillance for infectious diarrhea in Mentougou district of Beijing, 2013-2017

作　　者：吕秋艳[1] 李龙建[1] 刘海涛[1] 褚添 赵香菊[1] Lyn Qiuyan;Li Longjian;Liu Haitao;Chu Tian;Zhao Xiangju(Mentougou District Center for Disease Control and Prevention,Beijing 102300,China)

机构地区：[1]北京市门头沟区疾病预防控制中心

出　　处：《疾病监测》2019年第6期514-518,共5页Disease Surveillance

摘　　要：目的了解北京市门头沟区感染性腹泻患者粪便病原谱情况,为肠道传染病的预防控制提供参考依据。方法 2013-2017年,选择门头沟区就诊人数最多的2家医院,采集未用抗生素的腹泻患者粪便标本进行沙门菌、志贺菌、副溶血弧菌和5种致泻性大肠埃希菌(DEC)的分离培养和鉴定,并采用SPSS 20.0软件对病例资料进行χ^2检验统计学分析。结果共采集1 672例腹泻患者粪便标本,检出270株致病菌,总体阳性率为16.15%。其中DEC 121株(7.24%),副溶血弧菌65株(3.89%),沙门菌58株(3.47%),志贺菌3株(0.18%)。检出的DEC以肠产毒性大肠埃希菌为主,占比30.36%,沙门菌中肠炎沙门菌占比(8.50%)最高。另外,病原菌的检出有明显的季节性,5-8月检出率最高。从患者性别来看,男性和女性患者粪便的病原菌阳性率差异无统计学意义(χ^2=0.685,P>0.05)。结论 DEC在门头沟区腹泻患者粪便中检出率最高,其次是副溶血弧菌和沙门菌,应加强肠道病原菌的监测工作,尤其要密切关注腹泻患者粪便病原谱的变化,以指导感染性腹泻的防控工作。Objective To understand the pathogen spectrum of infectious diarrhea in Mentougou district of Beijing and provide evidence for prevention and control of intestinal infectious diseases.Methods Stool samples were collected from the diarrhea patients receiving no antibiotic treatment in two large hospitals in Mentougou for the isolation,culture and identifications of Salmonella,Shigella,Vibrio parahaemolyticus and 5 kinds of diarrheagenic Escherichia coli(DEC).The patient data were analyzed with SPSS 20.0.Results A total of 1 672 stool samples were collected from diarrheal patients,and270 strains of pathogenic bacteria were detected.The overall positive rate was 16.15%.Among these strains,121(7.24%) were DEC,65(3.89%) were V.parahaemolyticus,58(3.47%) were Salmonella,and 3(0.18%) were Shigella.Enterotoxigenic E.coli(ETEC) was the most common pathogen in DEC(30.36%),and Salmonella Enteritidis was the most common pathogen in Salmonella(8.50%).In addition,the detection of pathogenic bacteria had obvious seasonality.The detection rate was highest between May and August.There was no significant difference in detection rate between men and women(χ^2=0.685,P>0.05).Conclusion DEC was the main pathogen detected in stool samples of diarrhea patients in Mentougou,followed by V.parahaemolyticus and Salmonella.It is necessary to strengthen the surveillance for enteric pathogens,especially the pathogen spectrum of infectious diarrhea,for the prevention and control of infectious diarrhea.

关 键 词：腹泻 肠道病原菌 病原谱 

分 类 号：R378[医药卫生—病原生物学]