鼻渊通窍颗粒联合孟鲁司特治疗儿童变应性鼻炎的疗效观察  

Curative efficacy of Biyuan Tongqiao particles in combination with montelukast sodium for treatment of allergic rhinitis in children

作　　者：王然然 丁锋[2] 肖向丽 刘艳[2] 徐宝丽 WANG Ran-ran;DING Feng;XIAO Xiang-li;LIU Yan;XU Bao-li(Department of Pediatrics,Wuhan Red Cross Hospital,Wuhan 430015,China;Department of Otolaryngology,Hankou Hospital of Wuhan,Wuhan 430012,China;Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong Universityof Science and Technology,Wuhan 430022,China)

机构地区：[1]武汉市红十字会医院儿科,湖北武汉430015 [2]武汉市汉口医院耳鼻咽喉科,湖北武汉430012 [3]华中科技大学同济医学院附属协和医院药剂科,湖北武汉430022

出　　处：《中国耳鼻咽喉颅底外科杂志》2019年第3期304-308,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨鼻渊通窍颗粒联合孟鲁司特治疗儿童变应性鼻炎(allergic rhinitis,AR)的疗效.方法将150例4~12岁变应性鼻炎儿童患者随机分成两组,对照组口服孟鲁司特2周,观察组在对照组基础上同时口服鼻渊通窍颗粒2周,比较两组患儿治疗前后的临床症状视觉模拟评分(VAS)、疗效及复发率.结果对照组治疗后临床症状VAS评分分别为:鼻塞(2.99±1.493)分、流涕(1.40±0.973)分、打喷嚏(1.37±1.583)分、总分(5.76±3.533)分;观察组治疗后临床症状VAS评分分别为:鼻塞(1.81 ±1.036)分、流涕(0.64 ±0.880)分、打喷嚏(0.71 ±0.969)分、总分(3.16±2.331)分.两组患儿治疗后临床症状VAS评分均低于治疗前,经比较差异均有统计学意义(P均<0.05);观察组与对照组比较,治疗前临床症状VAS评分差异均无统计学意义(P均>0.05),治疗后VAS评分差异均有统计学意义(P均<0.05).观察组总有效率为97.3%,明显高于对照组的89.3%(P<0.05),观察组复发率为4.0%,明显低于对照组的16.0%(P <0.05).结论孟鲁司特联合鼻渊通窍颗粒治疗儿童变应性鼻炎可进一步提高疗效.Objective To investigate the curative efficacy of Biyuan Tongqiao particles in combination with montelukast sodium for treatment of allergic rhinitis in children. Methods A total of 150 children ( aged 4-12 years) with allergic rhinitis were randomly divided into two groups ( a treatment group and a control group). The control group received montelukast orally for 2 weeks. The observation group took oral administration of biyuantongqiao granules for 2 weeks on the basis of the control group. The clinical symptom Visual analogue scale ( VAS) scores,curative effect and recurrence rate were compared between the two groups before and after treatment. Results The VAS scores of clinical symptoms after treatment in the control group, respectively: nasal obstruction (2. 99 ± 1.493 ), rhinorrhea ( 1.40 ± 0. 973 ), sneezing (1.37 ± 1.583), total score (5. 76 ±3. 533);the VAS scores of clinical symptoms after treatment in the treatment group, respectively: nasal obstruction (1.81 ± 1.036), rhinorrhea(0. 64 ±0. 880), sneezing (0.71 ±0. 969), total score (3. 16 ± 2. 331). The all scores after treatment were lower than that before treatment( all P < 0. 05 ) in the two groups. There was no significant difference between the treatment group and the control group before treatment ( all P > 0. 05 ). There was significant difference between the treatment group and the control group after treatment( all P < 0. 05 ). The effective rate of the treatment group ( 97. 3%) was significantly higher than that of the control group ( 89. 3%)( P < 0. 05), and the recurrence rate of the treatment group(4. 0%) was significantly lower than that of the control group(16. 0%)(P <0. 05). Conclusion Montelukast sodium combined with biyuan tongqiao granule can improve the therapeutic effect of allergic rhinitis in children.

关 键 词：变应性鼻炎 儿童 孟鲁司特钠 鼻渊通窍颗粒 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]