高纯竹叶碳苷黄酮纳米材料的护肤功效  

Assessment on Skin Care Effect of the Nanomaterial Taking High Purity C-glycoside Flavonoids of Bamboo Leaf as Leading Material

作　　者：张宇靖 李云虹 姜春鹏 杨舒琪 韩建欣 张英[1] ZHANG Yu-jing;LI Yun-hong;JIANG Chun-peng;YANG Shu-qi;HAN Jian-xin;ZHANG Ying(Zhejiang Key Laboratory for Agro-Food Processing,Zhejiang R&D Center for Food Technology and Equipment,College of Biosystems Engineering and Food Science,Zhejiang University,Hangzhou 310058,Zhejiang,China;Suzhou Green Leaf Wholelife Health Technology Co.,Ltd. Shanghai Zhangjiang Postdoctoral Workstation,Shanghai201203,China)

机构地区：[1]浙江大学生物系统工程与食品科学学院,浙江省农产品加工技术研究重点实验室,浙江省食品加工技术与装备工程研究中心,浙江杭州310058 [2]苏州绿叶日用品有限公司上海张江博士后工作站,上海201203

出　　处：《精细化工》2019年第7期1401-1407,共7页Fine Chemicals

基　　金：国家重点基础研究发展规划(973计划)(2012CB720806)

摘　　要：在采用B16黑素瘤细胞体外评价高纯竹叶碳苷黄酮复合纳米材料(H-BLFnp)美白作用的基础上,基于临床医学理论进行人体实验,应用系列皮肤测试仪器,对受试者使用试样前后的皮肤含水量、水分散失量、光泽度、明亮度、黑色素含量、皮肤弹性等生理指标进行了测定,考察H-BLFnp在保湿、美白、延缓衰老方面的功效。结果显示,以β-熊果苷为阳性对照,H-BLFnp对B16细胞增殖、胞内酪氨酸酶活性和黑色素合成均有显著的抑制作用(p<0.05),当H-BLFnp质量浓度为100 mg/L时,其抑制率分别达到45.14%、72.55%和54.01%,即其可通过降低酪氨酸酶活性、抑制黑素细胞增殖和黑色素生成达到美白功效;人体实验结果显示:H-BLFnp能显著提高皮肤的水分含量、皮肤弹性、明亮度和光泽度,降低皮肤黑色素含量和经皮水分散失。Based on the whitening effect of a novel composite nanomaterial taking high purity C-glycoside flavonoids of bamboo leaf as leading material(H-BLFnp)evaluated by B16 melanoma cells in vitro,its skin care function was further evaluated on the human body.The indexes of biological efficacy including skin moisture content,percutaneous moisture loss,skin gloss,brightness,melanin content and skin elasticity were tested before and after subjects using the samples to explore the biological efficacy of H-BLFnp on the moisturizing,whitening,anti-aging.The results showed that H-BLFnp significantly inhibited B16 cell proliferation,tyrosinase activity and melanin synthesis takingβ-arbutin as a positive control(p<0.05),the corresponding inhibition rates achieved 45.14%,72.55%and 54.01%respectively when the concentration of H-BLFnp was at 100 mg/L.H-BLFnp may exert whitening effect through inhibiting melanocyte proliferation,tyrosinase activity and melanin synthesis.The clinic test revealed that H-BLFnp significantly increased skin moisture content,skin elasticity,brightness and gloss,and reduced skin melanin content and percutaneous moisture loss.

关 键 词：高纯竹叶碳苷黄酮 纳米材料 护肤功能因子 生物学功效 水感型化妆品 日化原料 

分 类 号：TQ658[化学工程—精细化工]