四烯甲萘醌软胶囊联合益肾固本祛痛汤治疗骨质疏松患者临床疗效  

Influence of Yishen Guben Qutong Decoction combined with tetraene naphthoquinone soft capsule on bone metabolism,bone conversion index and clinical efficacy in osteoporosis patients

作　　者：邱宏韬 林青 赖文强 曲震 肖庆华 朱建宗 QIU Hong-tao;LIN Qing;LAI Wen-qiang;QU-Zhen;XIAO Qing-hua;ZHU Jian-zong(Shenzhen Baoan Chinese Medicine Hospital (Group) Department of Orthopaedics,Shenzhen,Guangdong 518000;Shenzhen Traditional Chinese Medicine Hospital,Department of Orthopaedics,Shenzhen,Guangdong 518000;Shenzhen Baoan Sha Jing people's Hospita,Orthopaedics,Shenzhen,Guangdong 518000)

机构地区：[1]深圳市宝安中医院(集团)骨伤科 [2]深圳市中医院骨伤科 [3]深圳市宝安区沙井人民医院骨科,广东深圳518000

出　　处：《海南医学院学报》2019年第14期1092-1095,共4页Journal of Hainan Medical University

基　　金：广东省中医药局科研项目(20191292)~~

摘　　要：目的:观察四烯甲萘醌软胶囊联合益肾固本祛痛汤对骨质疏松患者骨代谢、骨转换指标的影响及其临床疗效。方法:纳入100例原发性骨质疏松症患者,将其分为对照组及观察组各50例,对照组予四烯甲萘醌软胶囊治疗,观察组在对照组治疗基础上联合益肾固本祛痛汤加减治疗,6个月为1个疗程。测定两组治疗前后骨代谢指标、骨密度变化情况及临床疗效。结果:观察组总有效率高于对照组(P<0.05);治疗后,观察组血钙(Ca)、血清碱性磷酸酶(ALP)和I型胶原交联C-末端肽(CTX-1)水平低于对照组(P<0.05);治疗后,观察组骨钙素(OC)高于对照组(P<0.05),而观察组腰椎L2-4、股骨颈、股骨大转子的骨密度值(BMD)均高于对照组(P<0.05)。结论:四烯甲萘醌软胶囊联合益肾固本祛痛汤对骨质疏松患者临床疗效较好,值得在临床上进一步推广。Objective:To observe the effect of tetradecylene naphthalene soft capsule combined with Yishen Gubenyutong Decoction on bone metabolism and bone turnover in patients with osteoporosis and its clinical efficacy.Methods:A total of 100 patients with primary osteoporosis(all were treated by our hospital from February 2017 to June 2018)were divided into two groups.The control group(50 cases)was given to menatetrenone capsules.Treatment,observation group(50 cases)combined with Yishen Gubenqiaotongtong on the basis of the treatment of the control group,6 months for a course of treatment.The bone metabolic markers,bone mineral density changes and clinical efficacy were measured before and after treatment.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the observation group showed serum calcium(Ca),serum alkaline phosphatase(ALP)and type I collagen.The level of cross-linked C-terminal peptide(CTX-1)was lower than that of the control group(P<0.05).After treatment,the osteocalcin(OC)in the observation group was higher than that in the control group(P<0.05),and the bone mineral density(BMD)of lumbar vertebrae L2-4,femoral neck and femur trochanter in the observation group were higher than those in the control group(P<0.05).Conclusion:Menatenaphthoquinone soft capsule combined with Yishen Gubenyutong Decoction has good clinical effect on osteoporosis patients and it is worth further promotion in clinic.

关 键 词：四烯甲萘醌软胶囊 益肾固本祛痛汤 骨质疏松 临床疗效 

分 类 号：R580[医药卫生—内分泌]