功能化分子筛催化氮杂环丙烷与异硫氰酸酯[3+2]环加成反应的研究  

Study On Cycloaddition Of Aziridines with Isothiocyanates Catalyzed by Functionlized Zeolite

作　　者：任鸿 盛丽丽 REN Hong;SHENG Li-li(Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China;Zhejiang Academy of Safety Science and Technology,Hangzhou,Zhejiang 310012,China)

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051 [2]浙江省安全生产科学研究院,浙江杭州310012

出　　处：《浙江化工》2019年第7期16-19,共4页Zhejiang Chemical Industry

摘　　要：主要研究了固体酸催化剂对氮杂环丙烷与异硫氰酸酯间的[3+2]环加成反应的催化效果,并对反应展开了一系列底物拓展。实验结果表明,在该催化体系下,反应都有不错的收率。并且通过催化剂重复性实验,也可以发现,经过多次重复利用的固体酸也可以起到有效的催化作用。In this research,an efficient,simple,and general route for the[3+2] cycloaddition reaction of aziridines with isothiocyanates been described using functionlized zeolite catalysis inair.Using SBA-15- PW as catalyst,a series of heterocycles were obtained from aziridines in good to high yields.Moreover, reusability study showed that the catalyst SBA-15-PW could be reused at least for 5 runs without losing significant catalytic activity after a simple washing.

关 键 词：氮杂环丙烷 异硫氰酸酯 功能化分子筛 环加成反应 

分 类 号：O621.251[理学—有机化学]