不同人乳头瘤病毒亚型感染与宫颈病变的相关性  

Relationship between Infections of Different Human Papillomavirus Genotypes and Cervical Lesions

作　　者：苗野[1] 阮强[1] 马艳萍[1] MIAO Ye;RUAN Qiang;MA Yanping(Virus Research Laboratory,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院病毒研究室

出　　处：《中国医科大学学报》2019年第7期606-610,614,共6页Journal of China Medical University

基　　金：辽宁省自然科学基金(20170541035)

摘　　要：目的探讨不同人乳头瘤病毒(HPV)亚型感染与宫颈病变的关系以及不同年龄患者中HPV亚型感染与宫颈病变的关系。方法回顾性分析于中国医科大学附属盛京医院就诊的1615例宫颈病变患者的临床资料,统计分析不同HPV亚型的感染情况及其与宫颈病变的关系;并按不同年龄分层,分析不同HPV亚型感染与宫颈病变的关系。结果HPV16亚型阳性检出率最高,HPV58、HPV53、HPV33次之。与宫颈病变有关的HPV亚型包括HPV16、HPV53、HPV58、HPV52、HPV42、HPV33、HPV56和HPV31。按不同年龄分层后,发现15~30岁患者中不同级别宫颈病变与HPV45有关,31~45岁患者中不同宫颈病变与HPV33、HPV56有关,46~60岁患者中不同宫颈病变与HPV16、HPV18有关,61岁以上患者中不同宫颈病变与HPV6、HPV16及HPV33有关。结论30岁以上的女性应定期进行HPV检测,对宫颈病变进行筛检,以加强对宫颈癌的预防。Objective To investigate the relationships between infections of different human papillomavirus( HPV) genotypes and cervical lesions and between infections of different HPV genotypes and cervical lesions in patients of different ages.Methods A total of 1 615 patients with cervical lesions who were admitted to Shengjing Hospital,China Medical University were retrospectively analyzed. The infection status of different HPV genotypes and their relationships with different types of cervical lesions were analyzed.The relationships between the infections of different HPV genotypes and cervical lesions were analyzed according to age stratification.Results The positivity rate of HPV16 was the highest,followed by those of HPV58,HPV53,and HPV33.HPV genotypes related to cervical lesions included HPV16,HPV53,HPV58,HPV52,HPV42,HPV33,HPV56,and HPV31.After stratification by age,we found that different grades of cervical lesions were related to HPV45 in 15- to 30-year-old patients;to HPV33 and HPV56 in 31- to 45-year-old patients;to HPV16 and HPV18 in 46- to 60-year-old patients;and to HPV6,HPV16,and HPV33 in patients older than 61 years of age.Conclusion Women older than 30 years of age should be regularly tested for HPV and screened for cervical lesions in order to strengthen the prevention of cervical cancer.

关 键 词：人乳头瘤病毒 年龄分布 宫颈病变 

分 类 号：R711.74[医药卫生—妇产科学]