血脂异常痰浊阻遏证患者丝氨酸代谢产物特点及其与体质量指数、中医证候积分的相关性研究  

Study on the characteristics of serine metabolites in patients with dyslipidemia and phlegm-dampness retention syndrome and their correlation with BMI index and TCM syndrome score

作　　者：陈婧 杨惠民[2] 叶超[2] 谭昕 李品慧 杨正 薛晓琳 CHEN Jing;YANG Huimin;YE Chao;TAN Xin;LI Pinhui;YANG Zheng;XUE Xiaolin(The Third Affiliated Hospital of Beijing University of TCM,Beijing 100029,China;Dongzhimen Hospital of Beijing University of TCM,Beijing 100700,China;The First Clinical Medical College of Liaoning Hospital of TCM,Shenyang 110847,Liaoning,China;Hainan Provincial Hospital of TCM,Haikou 570203;College of TTCM,Beijing University of TCM,Beijing 100029 China)

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]北京中医药大学东直门医院,北京100700 [3]辽宁中医药大学第一临床医学院,辽宁沈阳110847 [4]海南省中医院,海南海口570203 [5]北京中医药大学中医学院,北京100029

出　　处：《现代中西医结合杂志》2019年第22期2395-2398,2403,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：中央高校基本科研业务费专项基金资助项目(2014-JYBZZ-XS-135);教育部资助北京中医药大学自主课题(2180072120002);北京中医药大学新奥奖励基金(2018-XAJLJJ-026)

摘　　要：目的探讨血脂异常痰浊阻遏证患者的丝氨酸代谢产物特点及其丝氨酸代谢产物浓度与体质量指数(BMI)、中医证候积分的相关性。方法选择41例中医辨证为痰浊阻遏证血脂异常患者,应用代谢组学方法测定患者血清丝氨酸代谢产物丝氨酸和甘氨酸浓度,对患者进行中医证候积分量化证候程度,分析丝氨酸浓度与甘氨酸浓度间的相关性及丝氨酸和甘氨酸浓度与BMI、中医证候积分的相关性。结果血脂异常痰浊阻遏证患者丝氨酸浓度与甘氨酸浓度呈正相关(P<0.05);丝氨酸浓度和BMI呈负相关,但未显示统计学意义;甘氨酸浓度和BMI呈显著负相关(P<0.05);丝氨酸浓度、甘氨酸浓度与中医证候积分均呈显著负相关(P均<0.05)。结论血脂异常痰浊阻遏证患者丝氨酸代谢产物具有特征性变化,其变化特点与该病中医病因病机分析相一致,BMI、丝氨酸代谢产物浓度结合临床症状有可能成为评价该证型患者证候程度的参考指标,为揭示该疾病的中医病机及生物学特征提供了依据。Objective It is to explore the characteristics of serine metabolites in patients with dyslipidemia and phlegm-dampness retention syndrome and their correlation with BMI index and TCM syndrome scores.Methods Forty-one patients with dyslipidemia and phlegm-dampness retention syndrome were collected in which the concentrations of serum serine metabolites(serine and glycine)were determined by epidemiological cross-sectional investigation method and metabonomic detection method,and the syndrome degree of phlegm-dampness retention syndrome was quantified by TCM syndrome integral,and the correlation between the conc entrations of metabolites and BMI index and TCM syndrome integral was analyzed.Results There was a positive correlation between serine metabolites(serine,glycine)and dyslipidemia and phlegm-dampness retention syndrome(P<0.05),which was a characteristic change under this syndrome.Serine concentration was negatively correlated with BMI under dyslipidemia and phlegm-dampness retention syndrome,but there was no statistical significance.There was a significant negative correlation between glycine concentration and BMI(P<0.05).The concentration of serine metabolite serine and glycine under dyslipidemia and phlegm-dampness retention syndrome was significantly negatively correlated with the TCM syndrome score(P<0.05).Conclusion The serine metabolites in the patients with dyslipidemia and phlegm-dampness retention syndrome have characteristic changes,their characteristics are consistent with the analysis of TCM etiology and pathogenesis of this disease,and their BMI index and product concentration,combined with clinical symptoms,may become a reference for evaluating the degree of dyslipidemia and phlegm-dampness retention syndrome,providing a basis for revealing the TCM pathogenesis characteristics and biological basis of the disease and providing a basis for effective intervention of the disease.

关 键 词：血脂异常 痰浊阻遏证 丝氨酸代谢产物 体质量指数 中医证候积分 

分 类 号：R589.2[医药卫生—内分泌]