脂肪因子Omentin-1、脂联素与中老年女性骨密度相关性研究  

Correlation between adipokines Omentin-1,adiponectin and bone mineral density in middle-aged women

作　　者：陈丽华[1] 呂燕碧 邝雪辉[1] 康玉闻[1] 邓惠群[1] 刘永裕[1] CHEN Lihua;LU Yanbi;YAN Xuehui;KANG Yuwen;DENG Huiqun;LIU Yongyu(Department of Orthopaedics,Foshan Traditional Chinese Medicine Hospital,Foshan 528000,China)

机构地区：[1]佛山市中医院骨科

出　　处：《中国骨质疏松杂志》2019年第7期909-912,919,共5页Chinese Journal of Osteoporosis

摘　　要：目的观察脂肪因子Omentin-1、脂联素与中老年女性骨密度之间的相关性。方法选取2017年3月至2018年4月在佛山市中医院就诊的338名女性,按照绝经状态分为围绝经期/绝经期组(n=194)和绝经后组(n=124)。将参研人员年龄、体质量指数(bone mass index,BMI)、腰围、吸烟状况、身体活动、脂联素、Omentin-1和激素进行多变量调整(ANCOVA),用于研究其脂肪因子和骨密度(bone mineral density,BMD)之间的潜在关系。结果与绝经后女性的腰椎BMD [(0.69±0.08)g/cm^2]相比,围绝经期女性的腰椎BMD[(0.89±0.09)g/cm^2]更高;在围绝经期/绝经期组女性中,脂联素和Omentin-1均与腰椎BMD无显著相关性(P>0.05);在绝经后组女性中,脂联素与腰椎BMD无相关性(P>0.05);而在绝经后组女性中,Omentin-1与腰椎BMD呈显著负相关(P<0.05)。结论绝经后女性的Omentin-1与腰椎BMD呈负相关。Objective To observe the correlation between adipokines Omentin-1,adiponectin and bone mineral density in middleaged women. Methods 338 women who were admitted to our hospital from March 2017 to April 2018 were selected. According to the menopausal status,the menopausal/menopausal group( n = 194) and the postmenopausal group( n = 124) were divided.Multivariable-adjusted ANCOVA including age,BMI,waist circumference,smoking status,physical activity,adiponectin or Omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BMD. Results Peri-/premenopausal women had higher BMD of lumbar vertebrae( 0. 89±0. 09 g/cm^2),compared to postmenopausal women( 0. 69±0. 08 g/cm^2)( P<0. 05). In peri-/premenopausal women neither adiponectin nor Omentin-1 was significantly associated with BMD of lumbar vertebrae( P> 0. 05). In postmenopausal women,adiponectin was not associated with BMD of lumbar vertebrae( P >0. 05). In postmenopausal women,Omentin-1 was significantly negatively correlated with lumbar spine BMD( P < 0. 05).Conclusion Our study provides evidence for circulating Omentin-1 levels have an inverse correlation with BMD at the lumbar spine in postmenopausal women.

关 键 词：脂肪因子 网膜素1(Omentin-1) 脂联素 骨密度 绝经后女性 

分 类 号：R681[医药卫生—骨科学]