Notch信号通路在骨重建过程中的双向调节作用  

Bidirectional regulation of Notch signaling pathway during bone remodeling

作　　者：周灵通[1] 黄凯 宋敏[1] 刘小钰[1] 蒋林博 侯红燕 董万涛[1,2] ZHOU Lingtong;HUANG Kai;SONG Min;LIU Xiaoyu;JIAND Linbo;HOU Hongyan;DONG Wantao(Gansu University of Chinese Medicine,Lanzhou 730000;The Second Affiliated Hospital of Gansu University of TCM,Lanzhou 730020,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730020

出　　处：《中国骨质疏松杂志》2019年第7期1015-1020,共6页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金计划(1506RJZA048);甘肃省中医药管理局科研课题(GZK-2016-17);甘肃省财政厅基本科研业务课题(BH2010-428);甘肃中医药大学研究生创新基金(CX2017-01)

摘　　要：Notch信号通路对骨形成及骨吸收的刺激和抑制作用都被广泛报道,其在成骨细胞、骨细胞、破骨细胞、骨髓间充质干细胞等的生成或分化中的作用出现了"矛盾"的结果,表现为对于骨形成-骨吸收偶联关系的双向调节作用,可见,Notch信号通路对骨重建过程的影响并非单一的促进或抑制作用,本文就Notch信号通路对成骨细胞、破骨细胞、骨髓间充质干细胞生成、分化及功能的双向调节作用做一综述,以期为相关骨代谢疾病的研究思路提供参考。Notch signaling pathway has been widely reported for its stimulatory and inhibitory effects on bone formation and bone resorption. Its role in the formation or differentiation of osteoblasts,bone cells,osteoclasts,and bone marrow mesenchymal stem cells appears to be contradictory,and shows a kind of bidirectional regulation for the coupling of bone formation to bone resorption.The effect of Notch signaling pathway on bone remodeling process is not a single promotion or inhibition. This article reviews the role of Notch signaling pathway in the bidirectional regulation of osteoblasts,osteoclasts,and bone marrow mesenchymal stem cells.We hope to provide reference for relevant research ideas of bone metabolism diseases related to the Notch signaling pathway.

关 键 词：NOTCH信号通路 骨形成 骨吸收 骨重建 双向调节 

分 类 号：R563[医药卫生—呼吸系统]